Right heart adaptation to pulmonary arterial hypertension: physiology and pathobiology
Survival in patients with pulmonary arterial hypertension (PAH) is closely related to right
ventricular (RV) function. Although pulmonary load is an important determinant of RV systolic …
ventricular (RV) function. Although pulmonary load is an important determinant of RV systolic …
Smell and taste dysfunction in patients with COVID-19: a systematic review and meta-analysis
… Chin MClinPharm, PhD b c , Cornelia B. Landersdorfer PhD a , Danny Liew MBBS (Hons),
FRACP, … Kaye, CWD Chang, K. Kazahaya, J. Brereton, JC Denneny 3rd … Reips, K. Maag Merki …
FRACP, … Kaye, CWD Chang, K. Kazahaya, J. Brereton, JC Denneny 3rd … Reips, K. Maag Merki …
[HTML][HTML] Maternal and neonatal outcomes associated with COVID-19 infection: A systematic review
Background COVID-19 has created an extraordinary global health crisis. However, with
limited understanding of the effects of COVID-19 during pregnancy, clinicians and patients are …
limited understanding of the effects of COVID-19 during pregnancy, clinicians and patients are …
[HTML][HTML] Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
Background Health system planning requires careful assessment of chronic kidney disease
(CKD) epidemiology, but data for morbidity and mortality of this disease are scarce or non-…
(CKD) epidemiology, but data for morbidity and mortality of this disease are scarce or non-…
Nivolumab in patients with advanced gastric or gastro-oesophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO …
…, Y Hamamoto, JG Kim, K Chin, DY Oh, K Minashi… - The Lancet, 2017 - thelancet.com
Background Patients with advanced gastric or gastro-oesophageal junction cancer refractory
to, or intolerant of, two or more previous regimens of chemotherapy have a poor prognosis, …
to, or intolerant of, two or more previous regimens of chemotherapy have a poor prognosis, …
[PDF][PDF] A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes
RM Neve, K Chin, J Fridlyand, J Yeh, FL Baehner… - Cancer cell, 2006 - cell.com
Recent studies suggest that thousands of genes may contribute to breast cancer pathophysiologies
when deregulated by genomic or epigenomic events. Here, we describe a model "…
when deregulated by genomic or epigenomic events. Here, we describe a model "…
Avelumab in patients with chemotherapy-refractory metastatic Merkel cell carcinoma: a multicentre, single-group, open-label, phase 2 trial
…, I Brownell, KD Lewis, JH Lorch, K Chin… - The lancet …, 2016 - thelancet.com
Background Merkel cell carcinoma is a rare, aggressive skin cancer with poor prognosis in
patients with advanced disease. Current standard care uses various cytotoxic chemotherapy …
patients with advanced disease. Current standard care uses various cytotoxic chemotherapy …
Pembrolizumab versus paclitaxel for previously treated, advanced gastric or gastro-oesophageal junction cancer (KEYNOTE-061): a randomised, open-label …
…, R Passalacqua, V Montesarchio, H Hara, K Chin… - The Lancet, 2018 - thelancet.com
Background Patients with advanced gastric or gastro-oesophageal junction cancer that
progresses on chemotherapy have poor outcomes. We compared pembrolizumab with paclitaxel …
progresses on chemotherapy have poor outcomes. We compared pembrolizumab with paclitaxel …
[PDF][PDF] Genomic and transcriptional aberrations linked to breast cancer pathophysiologies
K Chin, S DeVries, J Fridlyand, PT Spellman… - Cancer cell, 2006 - cell.com
This study explores the roles of genome copy number abnormalities (CNAs) in breast cancer
pathophysiology by identifying associations between recurrent CNAs, gene expression, …
pathophysiology by identifying associations between recurrent CNAs, gene expression, …
Zoonotic host diversity increases in human-dominated ecosystems
Land use change—for example, the conversion of natural habitats to agricultural or urban
ecosystems—is widely recognized to influence the risk and emergence of zoonotic disease in …
ecosystems—is widely recognized to influence the risk and emergence of zoonotic disease in …