Systemic sclerosis (SSc) is an orphan, complex, inflammatory disease affecting the immune
system and connective tissue. SSc stands out as a severely incapacitating and life-…

Objective To assess the prevalence of primary cardiac complications in a large population
of patients with systemic sclerosis (SSc), using recently developed echocardiographic …

Background: The osteoarticular and soft tissue structures of the hand may be involved in
systemic sclerosis (SSc), causing functional disability. Objective: To assess radiological hand …

Chronic recurrent multifocal osteomyelitis (CRMO), also known as chronic nonbacterial
osteomyelitis, is an orphan disease that manifests as recurrent flares of inflammatory bone pain …

Pachydermoperiostosis, or primary hypertrophic osteoarthropathy (PHO), is an inherited
multisystem disorder, whose features closely mimic the reactive osteoarthropathy that …

Objective. Anticyclic citrullinated peptide antibodies (anti-CCP) are considered specific markers
of rheumatoid arthritis (RA) and have been included in the revised classification criteria …

Objective. Barrett’s oesophagus (BE) is the major risk factor for oesophageal adenocarcinoma
(EAC). SSc is associated with an increased risk of BE related to chronic reflux. The aim of …

Objective. To assess the prevalence and potential associations with the systemic sclerosis (SSc)
phenotype of additional autoimmune diseases (AID). Methods. A multicenter study was …

… Wipff MD, PhD a , M. Forien MD c , M. Dougados MD, PhD d , C. … Wipff, C. Job-Deslandre,
et al. …

Among the connective tissue diseases, systemic sclerosis is an orphan disease in which
diffuse connective tissue alterations lead to multi-organ involvement. Environmental factors …