Long-term intratracheal lipopolysaccharide exposure in mice results in chronic lung inflammation and persistent pathology

JHJ Vernooy, MA Dentener, RJ Van Suylen… - American journal of …, 2002 - atsjournals.org
Lipopolysaccharide (LPS), a major proinflammatory glycolipid component of the gram-negative
bacterial cell wall, is one of the agents ubiquitously present as contaminant on airborne …

Increased activity of matrix metalloproteinase-8 and matrix metalloproteinase-9 in induced sputum from patients with COPD

JHJ Vernooy, JHN Lindeman, JA Jacobs… - Chest, 2004 - Elsevier
Background: The increased expression of matrix metalloproteinases (MMPs) is considered
to be a key factor in the development of COPD. Net MMP activity represents a tightly …

Systemic inflammation in chronic obstructive pulmonary disease: the role of exacerbations

…, MA Dentener, JHJ Vernooy - Proceedings of the …, 2007 - atsjournals.org
The systemic manifestations of chronic obstructive pulmonary disease (COPD) exacerbations
are recognized, but our understanding of their etiology and importance is lacking largely …

Systemic and local inflammation in asthma and chronic obstructive pulmonary disease: is there a connection?

…, NL Reynaert, MA Dentener, JHJ Vernooy - Proceedings of the …, 2009 - atsjournals.org
Increasing evidence indicates that chronic obstructive pulmonary disease (COPD) and
probably asthma are associated with low-grade systemic inflammatory changes. In patients with …

Production of the acute-phase protein lipopolysaccharide-binding protein by respiratory type II epithelial cells: implications for local defense to bacterial endotoxins

…, PHM Hoet, JHJ Vernooy… - American journal of …, 2000 - atsjournals.org
This study demonstrates for the first time that respiratory epithelial cells are able to produce
the acute phase protein lipopolysaccharide (LPS)–binding protein (LBP), which is known to …

Myeloperoxidase deficiency attenuates lipopolysaccharide-induced acute lung inflammation and subsequent cytokine and chemokine production

…, BT Mossman, EFM Wouters, JHJ Vernooy - The Journal of …, 2009 - journals.aai.org
Lung neutrophilia is common to a variety of lung diseases. The production of reactive oxygen
and nitrogen species during neutrophil oxidative burst has been associated with protein …

Enhanced pulmonary leptin expression in patients with severe COPD and asymptomatic smokers

JHJ Vernooy, NEA Drummen, RJ Van Suylen… - Thorax, 2009 - thorax.bmj.com
Background: Chronic obstructive pulmonary disease (COPD) is characterised by an
abnormal inflammatory reaction of the lungs involving activation of epithelial cells. Leptin is a …

Intratracheal instillation of lipopolysaccharide in mice induces apoptosis in bronchial epithelial cells: no role for tumor necrosis factor-α and infiltrating neutrophils

JHJ Vernooy, MA Dentener, RJ van Suylen… - American Journal of …, 2001 - atsjournals.org
This study investigated apoptosis in lungs after local exposure to lipopolysaccharide (LPS).
Mice were instilled intratracheally with 5 μ g LPS, which corresponds to the amount acquired …

Optimising experimental research in respiratory diseases: an ERS statement

…, UA Maus, P Reinhold, JHJ Vernooy… - European …, 2018 - Eur Respiratory Soc
Experimental models are critical for the understanding of lung health and disease and are
indispensable for drug development. However, the pathogenetic and clinical relevance of the …

Leptin as regulator of pulmonary immune responses: involvement in respiratory diseases

JHJ Vernooy, NDJ Ubags, GG Brusselle… - Pulmonary …, 2013 - Elsevier
Leptin is an adipocyte-derived hormone, recognized as a critical mediator of the balance
between food intake and energy expenditure by signalling through its functional receptor (Ob-…