Long-term intratracheal lipopolysaccharide exposure in mice results in chronic lung inflammation and persistent pathology
JHJ Vernooy, MA Dentener, RJ Van Suylen… - American journal of …, 2002 - atsjournals.org
Lipopolysaccharide (LPS), a major proinflammatory glycolipid component of the gram-negative
bacterial cell wall, is one of the agents ubiquitously present as contaminant on airborne …
bacterial cell wall, is one of the agents ubiquitously present as contaminant on airborne …
Increased activity of matrix metalloproteinase-8 and matrix metalloproteinase-9 in induced sputum from patients with COPD
JHJ Vernooy, JHN Lindeman, JA Jacobs… - Chest, 2004 - Elsevier
Background: The increased expression of matrix metalloproteinases (MMPs) is considered
to be a key factor in the development of COPD. Net MMP activity represents a tightly …
to be a key factor in the development of COPD. Net MMP activity represents a tightly …
Systemic inflammation in chronic obstructive pulmonary disease: the role of exacerbations
…, MA Dentener, JHJ Vernooy - Proceedings of the …, 2007 - atsjournals.org
The systemic manifestations of chronic obstructive pulmonary disease (COPD) exacerbations
are recognized, but our understanding of their etiology and importance is lacking largely …
are recognized, but our understanding of their etiology and importance is lacking largely …
Systemic and local inflammation in asthma and chronic obstructive pulmonary disease: is there a connection?
…, NL Reynaert, MA Dentener, JHJ Vernooy - Proceedings of the …, 2009 - atsjournals.org
Increasing evidence indicates that chronic obstructive pulmonary disease (COPD) and
probably asthma are associated with low-grade systemic inflammatory changes. In patients with …
probably asthma are associated with low-grade systemic inflammatory changes. In patients with …
Production of the acute-phase protein lipopolysaccharide-binding protein by respiratory type II epithelial cells: implications for local defense to bacterial endotoxins
…, PHM Hoet, JHJ Vernooy… - American journal of …, 2000 - atsjournals.org
This study demonstrates for the first time that respiratory epithelial cells are able to produce
the acute phase protein lipopolysaccharide (LPS)–binding protein (LBP), which is known to …
the acute phase protein lipopolysaccharide (LPS)–binding protein (LBP), which is known to …
Myeloperoxidase deficiency attenuates lipopolysaccharide-induced acute lung inflammation and subsequent cytokine and chemokine production
…, BT Mossman, EFM Wouters, JHJ Vernooy - The Journal of …, 2009 - journals.aai.org
Lung neutrophilia is common to a variety of lung diseases. The production of reactive oxygen
and nitrogen species during neutrophil oxidative burst has been associated with protein …
and nitrogen species during neutrophil oxidative burst has been associated with protein …
Enhanced pulmonary leptin expression in patients with severe COPD and asymptomatic smokers
JHJ Vernooy, NEA Drummen, RJ Van Suylen… - Thorax, 2009 - thorax.bmj.com
Background: Chronic obstructive pulmonary disease (COPD) is characterised by an
abnormal inflammatory reaction of the lungs involving activation of epithelial cells. Leptin is a …
abnormal inflammatory reaction of the lungs involving activation of epithelial cells. Leptin is a …
Intratracheal instillation of lipopolysaccharide in mice induces apoptosis in bronchial epithelial cells: no role for tumor necrosis factor-α and infiltrating neutrophils
JHJ Vernooy, MA Dentener, RJ van Suylen… - American Journal of …, 2001 - atsjournals.org
This study investigated apoptosis in lungs after local exposure to lipopolysaccharide (LPS).
Mice were instilled intratracheally with 5 μ g LPS, which corresponds to the amount acquired …
Mice were instilled intratracheally with 5 μ g LPS, which corresponds to the amount acquired …
Optimising experimental research in respiratory diseases: an ERS statement
…, UA Maus, P Reinhold, JHJ Vernooy… - European …, 2018 - Eur Respiratory Soc
Experimental models are critical for the understanding of lung health and disease and are
indispensable for drug development. However, the pathogenetic and clinical relevance of the …
indispensable for drug development. However, the pathogenetic and clinical relevance of the …
Leptin as regulator of pulmonary immune responses: involvement in respiratory diseases
JHJ Vernooy, NDJ Ubags, GG Brusselle… - Pulmonary …, 2013 - Elsevier
Leptin is an adipocyte-derived hormone, recognized as a critical mediator of the balance
between food intake and energy expenditure by signalling through its functional receptor (Ob-…
between food intake and energy expenditure by signalling through its functional receptor (Ob-…