Adenocarcinoma in situ and minimally invasive adenocarcinoma are the pre-invasive forms
of lung adenocarcinoma. The genomic and immune profiles of these lesions are poorly …

Pan and Malaise traps have been used widely to sample insect abundance and diversity,
but no studies have compared their performance for sampling pollinators in forested …

Recent genome sequencing efforts have identified millions of somatic mutations in cancer.
However, the functional impact of most variants is poorly understood. Here we characterize …

To compare lung adenocarcinoma (ADC) and lung squamous cell carcinoma (SqCC) and to
identify new drivers of lung carcinogenesis, we examined the exome sequences and copy …

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing
molecular features of squamous cell carcinomas (SCCs) from five sites associated with …

Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we
report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, …

BACKGROUND. Comprehensive genomic profiling of a patient’s cancer can be used to
diagnose, monitor, and recommend treatment. Clinical implementation of tumor profiling in an …

Crucial transitions in cancer—including tumor initiation, local expansion, metastasis, and
therapeutic resistance—involve complex interactions between cells within the dynamic tumor …

Assessing the scope and severity of threats is necessary for evaluating impacts on populations
to inform conservation planning. Quantitative threat assessment often requires monitoring …

Whole-genome doubling (WGD) is common in human cancers, occurring early in tumorigenesis
and generating genetically unstable tetraploid cells that fuel tumour development 1 , 2 . …