Background— Extracellular matrix expansion is a key element of ventricular remodeling
and a potential therapeutic target. Cardiovascular magnetic resonance (CMR) T 1 -mapping …

In heart failure with preserved ejection fraction (HFpEF), the occurrence of myocardial fibrosis
is associated with adverse outcome. Whether pirfenidone, an oral antifibrotic agent without …

Background Blood–brain barrier (BBB) disruption has been noted in animal models of
Parkinson’s disease (PD) and forms the basis of the vascular hypothesis of neurodegeneration, …

PURPOSE: There is considerable interest in developing non-invasive methods of mapping
tumor hypoxia. Changes in tissue oxygen concentration produce proportional changes in the …

Purpose Pregnancy complications such as preeclampsia and fetal growth restriction are
sometimes thought to be caused by placental abnormalities associated with reduced …

Objectives : This study sought to evaluate the diagnostic performance of multiparametric
cardiovascular magnetic resonance (CMR) for detecting cardiac allograft vasculopathy (CAV) …

Magnetic resonance imaging has shown promise for evaluating tissue oxygenation. In this
study differences in the tissue longitudinal relaxation rate (R 1 ) and effective transverse …

Molecular oxygen has been previously shown to shorten longitudinal relaxation time (T 1 )
in the spleen and renal cortex, but not in the liver or fat. In this study, the magnitude and …

Background The PIROUETTE (PIRfenidOne in patients with heart failUre and preserved lEfT
venTricular Ejection fraction) trial is designed to evaluate the efficacy and safety of the anti-…

Purpose There is a clinical need for noninvasive, nonionizing imaging biomarkers of tumor
hypoxia and oxygenation. We evaluated the relationship of T 1 ‐weighted oxygen‐enhanced …