Background Asthma is a heterogeneous disease in which there is a differential response to
asthma treatments. This heterogeneity needs to be evaluated so that a personalized …

Background In allergic asthma, exposure to relevant antigens leads to an early asthmatic
response (EAR) followed, in certain subjects, by a late asthmatic response (LAR). Although …

Rationale: Nuclear factor (NF)-κB is a transcription factor known to regulate the expression
of many inflammatory genes, including cytokines, chemokines, and adhesion molecules. NF-…

Nitric oxide (NO), synthesised by different isoforms of nitric oxide synthase (NOS), has been
linked with the development and maintenance of nociception. We studied the role of the …

Background The role of IL-17 immunity is well established in patients with inflammatory
diseases, such as psoriasis and inflammatory bowel disease, but not in asthmatic patients, in …

Clinically, inflammatory pain is far more persistent than that typically modelled pre-clinically,
with the majority of animal models focussing on short-term effects of the inflammatory pain …

House dust mite (HDM) is the major source of allergen in house dust and is strongly
associated with the development of asthma. HDM can evoke a direct, nonallergic inflammatory …

Abediterol is a novel potent, long-acting inhaled β 2 -adrenoceptor agonist in development
for the treatment of asthma and chronic obstructive pulmonary disease. Abediterol shows …

Janus kinases (JAKs) have a key role in regulating the expression and function of relevant
inflammatory cytokines involved in asthma and chronic obstructive pulmonary disease. …

The Janus-activated kinase (JAK) family together with signal transducer and activator of
transcription (STAT) signaling pathway has a key role in regulating the expression and function …