Regression of electrocardiographic left ventricular hypertrophy during antihypertensive treatment and the prediction of major cardiovascular events

…, S Snapinn, KE Harris, P Aurup, JM Edelman… - Jama, 2004 - jamanetwork.com
ContextElectrocardiographic left ventricular hypertrophy (LVH) is a strong predictor of
cardiovascular (CV) morbidity and mortality. However, the predictive value of changes in the …

Regression of hypertensive left ventricular hypertrophy by losartan compared with atenolol: the Losartan Intervention for Endpoint Reduction in Hypertension (LIFE) …

…, J Rokkedal, KE Harris, JM Edelman… - Circulation, 2004 - Am Heart Assoc
Background— An echocardiographic substudy of the Losartan Intervention for Endpoint
Reduction in Hypertension (LIFE) trial was designed to test the ability of losartan to reduce left …

Intravenous augmentation treatment and lung density in severe α1 antitrypsin deficiency (RAPID): a randomised, double-blind, placebo-controlled trial

…, JM Stocks, BC Stoel, L Huang, Z Yao, JM Edelman… - The Lancet, 2015 - thelancet.com
Background The efficacy of α1 proteinase inhibitor (A1PI) augmentation treatment for α1
antitrypsin deficiency has not been substantiated by a randomised, placebo-controlled trial. CT-…

Risk of new-onset diabetes in the Losartan Intervention For Endpoint reduction in hypertension study

…, S Oparil, H Wedel, P Aurup, JM Edelman… - Journal of …, 2002 - journals.lww.com
Background There has been uncertainty about the risk of new-onset diabetes in hypertensive
individuals treated with different blood pressure-decreasing drugs. Objectives To study this …

Regression of electrocardiographic left ventricular hypertrophy and decreased incidence of new-onset atrial fibrillation in patients with hypertension

…, S Julius, LH Lindholm, MS Nieminen, JM Edelman… - Jama, 2006 - jamanetwork.com
ContextAtrial fibrillation (AF) is associated with increased risk of mortality and cardiovascular
events, particularly stroke, making prevention of new-onset AF a clinical priority. Although …

Regression of electrocardiographic left ventricular hypertrophy by losartan versus atenolol: The Losartan Intervention For Endpoint reduction in Hypertension (LIFE) …

…, S Snapinn, KE Harris, P Aurup, JM Edelman… - Circulation, 2003 - Am Heart Assoc
Background— Electrocardiographic left ventricular hypertrophy (LVH) predicts cardiovascular
morbidity and mortality, and regression of ECG LVH may predict improved prognosis in …

Oral montelukast compared with inhaled salmeterol to prevent exercise-induced bronchoconstriction: a randomized, double-blind trial

JM Edelman, JA Turpin, EA Bronsky… - Annals of internal …, 2000 - acpjournals.org
Background: Montelukast, an oral, once-daily leukotriene receptor antagonist, provides
protection against exercise-induced bronchoconstriction. Objective: To evaluate the effect of 8 …

Long-term efficacy and safety of α1 proteinase inhibitor treatment for emphysema caused by severe α1 antitrypsin deficiency: an open-label extension trial (RAPID …

…, MA Tortorici, M Fries, JM Edelman… - The Lancet …, 2017 - thelancet.com
Background Purified α1 proteinase inhibitor (A1PI) slowed emphysema progression in patients
with severe α1 antitrypsin deficiency in a randomised controlled trial (RAPID-RCT), which …

All-cause and cardiovascular mortality in relation to changing heart rate during treatment of hypertensive patients with electrocardiographic left ventricular hypertrophy

…, S Julius, DA Hille, B Dahlöf, JM Edelman… - European Heart …, 2010 - academic.oup.com
Background Although higher heart rate (HR) at baseline has been associated with an increased
risk of cardiovascular (CV) and all-cause mortality, the relationship of in-treatment HR …

Hospitalizations for new heart failure among subjects with diabetes mellitus in the RENAAL and LIFE studies

…, PA Lyle, SM Snapinn, Z Zhang, JM Edelman… - The American journal of …, 2005 - Elsevier
We sought to study the risk factors for heart failure (HF) and the relation between antihypertensive
treatment with losartan and the first hospitalization for HF in patients with diabetes …