Fibroblast growth factor 9 (FGF9) is necessary for fetal lung development and is expressed
by epithelium and mesothelium. We evaluated the role of FGF9 overexpression on adenoviral…

Ectopic formation of secondary lymphoid tissue is initiated by the local attraction of naive T
and B cells. In this study, we describe a novel type of organized lymphoid structure in the lung …

Background: Oxidative stress, resulting from the increased oxidative burden and decreased
level of antioxidant proteins, plays a role in the pathophysiology of smoking-related …

Rationale: There is growing evidence that resident cells, such as fibroblasts and epithelial
cells, can drive the persistent accumulation of dendritic cells (DCs) in chronically inflamed …

Idiopathic pulmonary fibrosis (IPF) is characterized by an accumulation of extracellular matrix
proteins and fibroblasts in the distal airways. Key developmental lung signaling pathways …

The organization of collagen during fibrotic processes is poorly characterized because of the
lack of appropriate methodologies. Here we show that multimodal multiphoton microscopy …

Idiopathic pulmonary fibrosis (IPF) is a devastating disease of unknown cause. Key signaling
developmental pathways are aberrantly expressed in IPF. The hedgehog pathway plays a …

Rationale: Lung dendritic cells (DCs) have been shown to accumulate in human fibrotic lung
disease, but little is known concerning a role for DCs in the pathogenesis of fibrotic lung. …

Serotonin (5-hydroxytryptamine; 5-HT) is known to increase proliferation and collagen
synthesis by fibroblasts. Two receptor subtypes, 5-HT2A and 5-HT2B, have been shown to play …

Rationale: Injury to alveolar epithelial cells is central to the pathophysiology of idiopathic
pulmonary fibrosis (IPF). An abnormal autoimmune response directed against antigens of the …