User profiles for Joel N. Kline

Joel N Kline

Professor of Medicine, University of Iowa
Verified email at uiowa.edu
Cited by 14623

TLR4 mutations are associated with endotoxin hyporesponsiveness in humans

NC Arbour, E Lorenz, BC Schutte, J Zabner, JN Kline… - Nature …, 2000 - nature.com
There is much variability between individuals in the response to inhaled toxins, but it is not
known why certain people develop disease when challenged with environmental agents and …

Motile cilia of human airway epithelia are chemosensory

AS Shah, Y Ben-Shahar, TO Moninger, JN Kline… - Science, 2009 - science.org
Cilia are microscopic projections that extend from eukaryotic cells. There are two general
types of cilia; primary cilia serve as sensory organelles, whereas motile cilia exert mechanical …

Cutting edge: modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma

JN Kline, TJ Waldschmidt, TR Businga… - The Journal of …, 1998 - journals.aai.org
Asthma has been increasing in industrialized countries. Evidence suggests that asthma is
caused by a Th2 immune response to inhaled environmental Ags and that childhood …

Bronchial thermoplasty: long-term safety and effectiveness in patients with severe persistent asthma

…, G Cox, DH Sterman, K Hogarth, JN Kline… - Journal of allergy and …, 2013 - Elsevier
… JN Kline has received a grant and travel support from Asthmatx and has received grants
from GSK, Teva, Boehringer Ingelheim, Pearl Therapeutics, and Genentech. AH Mansur has …

Omalizumab pretreatment decreases acute reactions after rush immunotherapy for ragweed-induced seasonal allergic rhinitis

TB Casale, WW Busse, JN Kline, ZK Ballas… - Journal of Allergy and …, 2006 - Elsevier
BACKGROUND: Rush immunotherapy (RIT) presents an attractive alternative to standard
immunotherapy. However, RIT carries a much greater risk of acute allergic reactions, including …

Health effects of airborne exposures from concentrated animal feeding operations

…, T Sigsgaard, PS Thorne, JN Kline… - Environmental …, 2007 - ehp.niehs.nih.gov
Toxic gases, vapors, and particles are emitted from concentrated animal feeding operations
(CAFOs) into the general environment. These include ammonia, hydrogen sulfide, carbon …

Phase I/II randomized trial of aerobic exercise in Parkinson disease in a community setting

…, V Magnotta, JD Dawson, TR Thomsen, JN Kline… - Neurology, 2014 - AAN Enterprises
Objectives: To (1) investigate effects of aerobic walking on motor function, cognition, and quality
of life in Parkinson disease (PD), and (2) compare safety, tolerability, and fitness benefits …

Intestinal helminths protect in a murine model of asthma

…, DE Elliott, JV Weinstock, JN Kline - The Journal of …, 2006 - journals.aai.org
Underdeveloped nations are relatively protected from the worldwide asthma epidemic; the
hygiene hypothesis suggests this is due to suppression of Th2-mediated inflammation by …

Variable airway responsiveness to inhaled lipopolysaccharide

JN Kline, JD Cowden, GW HUNNINGHAKE… - American journal of …, 1999 - atsjournals.org
Individuals exposed to inhaled endotoxin (lipopolysaccharide [LPS]) can develop airway
symptomatology and exacerbations of asthma. Moreover, among those occupationally exposed …

MMP9 modulates tight junction integrity and cell viability in human airway epithelia

…, S Keshavjee, P Karp, JN Kline… - … of Physiology-Lung …, 2009 - journals.physiology.org
The family of zinc- and calcium-dependent matrix metalloproteases (MMPs) play an important
role in remodeling of the airways in disease. Transcriptional regulation by proinflammatory …