Mutational spectrum of the WFS1 gene in Wolfram syndrome, nonsyndromic hearing impairment, diabetes mellitus, and psychiatric disease

…, TA Sivakumaran, JMW Van den Ouweland… - Human …, 2003 - Wiley Online Library
WFS1 is a novel gene and encodes an 890 amino‐acid glycoprotein (wolframin),
predominantly localized in the endoplasmic reticulum. Mutations in WFS1 underlie autosomal …

Targeted Inactivation of Mouse RAD52Reduces Homologous Recombination but Not Resistance to Ionizing Radiation

T Rijkers, J Van Den Ouweland, B Morolli… - … and cellular biology, 1998 - Taylor & Francis
The RAD52 epistasis group is required for recombinational repair of double-strand breaks (DSBs)
and shows strong evolutionary conservation. In Saccharomyces cerevisiae, RAD52 is …

High intraindividual variation of B-type natriuretic peptide (BNP) and amino-terminal proBNP in patients with stable chronic heart failure

…, FPL van der Dijs, JMW van den Ouweland… - Clinical …, 2004 - academic.oup.com
Background: Plasma B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP)
are promising markers for heart failure diagnosis, prognosis, and treatment. Insufficient data …

Reduced vitamin K status as a potentially modifiable risk factor of severe coronavirus disease 2019

…, JMW van den Ouweland, PA de Jong… - Clinical Infectious …, 2021 - academic.oup.com
Background Respiratory failure and thromboembolism are frequent in severe acute respiratory
syndrome coronavirus 2–infected patients. Vitamin K activates both hepatic coagulation …

Vitamin D deficiency in COVID-19: Mixing up cause and consequence

J Smolders, J van den Ouweland… - Metabolism …, 2021 - metabolismjournal.com
Recently, Chakhtoura et al. discussed the possible role of vitamin D supplements in Coronavirus
disease 2019 (COVID-19) in this journal [1]. COVID-19 is characterized by a systemic …

[HTML][HTML] Effects of Vitamin D and K on Interleukin-6 in COVID-19

…, JMW van den Ouweland, H van Daal… - Frontiers in …, 2022 - frontiersin.org
Background Pathology during COVID-19 infection arises partly from an excessive inflammatory
response with a key role for interleukin (IL)-6. Both vitamin D and K have been proposed …

[HTML][HTML] Vitamin D, magnesium, calcium, and their interaction in relation to colorectal cancer recurrence and all-cause mortality

…, BME Hansson, J Van Den Ouweland… - The American journal of …, 2020 - Elsevier
Background Higher concentrations of 25-hydroxyvitamin D 3 [25(OH)D 3 ] at diagnosis are
associated with a lower mortality risk in colorectal cancer (CRC) patients. However, …

Reduced vitamin K status as a potentially modifiable prognostic risk factor in COVID-19

…, JMW van den Ouweland, TM Hackeng, PA de Jong… - 2020 - preprints.org
Background: A significant proportion of SARS-CoV-2-infected patients develops respiratory
failure. Thromboembolism is also prevalent in coronavirus disease 2019 (Covid-19). Vitamin …

Various calibration procedures result in optimal standardization of routinely used 25 (OH) D ID-LC-MS/MS methods

…, AE van Herwaarden, JMW van den Ouweland… - Clinica chimica acta, 2016 - Elsevier
Background The variety of LC-MS/MS methods measuring total 25(OH)D used today is vast
and the comparability among these methods is still not well assessed. Methods Here, we …

Interlaboratory comparison of 25-hydroxyvitamin D assays: Vitamin D Standardization Program (VDSP) Intercomparison Study 2—Part 1 liquid chromatography …

…, F Ivison, R Fischer, JMW van den Ouweland… - Analytical and …, 2022 - Springer
An interlaboratory comparison study was conducted by the Vitamin D Standardization
Program (VDSP) to assess the performance of liquid chromatography – tandem mass …