[HTML][HTML] Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study

RJ Allen, J Porte, R Braybrooke, C Flores… - The Lancet respiratory …, 2017 - thelancet.com
Background Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with
high mortality, uncertain cause, and few treatment options. Studies have identified a significant …

Lysophosphatidic acid induces αvβ6 integrin-mediated TGF-β activation via the LPA2 receptor and the small G protein Gαq

MY Xu, J Porte, AJ Knox, PH Weinreb, TM Maher… - The American journal of …, 2009 - Elsevier
Activation of latent transforming growth factor β (TGF-β) by αvβ6 integrin is critical in the
pathogenesis of lung injury and fibrosis. We have previously demonstrated that the stimulation of …

[HTML][HTML] An epithelial biomarker signature for idiopathic pulmonary fibrosis: an analysis from the multicentre PROFILE cohort study

TM Maher, E Oballa, JK Simpson, J Porte… - The Lancet …, 2017 - thelancet.com
Background Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disorder with a variable
disease trajectory. The aim of this study was to assess potential biomarkers to predict …

[PDF][PDF] The COP9/signalosome complex is conserved in fission yeast and has a role in S phase

KE Mundt, J Porte, JM Murray, C Brikos… - Current biology, 1999 - cell.com
The COP9/signalosome complex is conserved from plant to mammalian cells. In Arabidopsis,
it regulates the nuclear abundance of COP1, a transcriptional repressor of …

αvβ6 integrin may be a potential prognostic biomarker in interstitial lung disease

G Saini, J Porte, PH Weinreb… - European …, 2015 - Eur Respiratory Soc
Idiopathic pulmonary fibrosis (IPF) and fibrotic nonspecific interstitial pneumonitis are
progressive interstitial lung diseases (ILDs) with limited treatment options and poor survival. …

[HTML][HTML] Influenza promotes collagen deposition via αvβ6 integrin-mediated transforming growth factor β activation

…, VA Meliopoulos, A Habgood, AL Tatler, J Porte… - Journal of Biological …, 2014 - ASBMB
Influenza infection exacerbates chronic pulmonary diseases, including idiopathic pulmonary
fibrosis. A central pathway in the pathogenesis of idiopathic pulmonary fibrosis is epithelial …

[HTML][HTML] Forced vital capacity trajectories in patients with idiopathic pulmonary fibrosis: a secondary analysis of a multicentre, prospective, observational cohort

…, RJ Allen, LM Kraven, WA Fahy, J Porte… - The Lancet Digital …, 2022 - thelancet.com
Background Idiopathic pulmonary fibrosis is a progressive fibrotic lung disease with a
variable clinical trajectory. Decline in forced vital capacity (FVC) is the main indicator of …

[HTML][HTML] Amplification of TGFβ induced ITGB6 gene transcription may promote pulmonary fibrosis

AL Tatler, AT Goodwin, O Gbolahan, G Saini, J Porte… - PloS one, 2016 - journals.plos.org
Idiopathic pulmonary fibrosis (IPF) is a devastating, progressive disease with poor survival
rates and limited treatment options. Upregulation of αvβ6 integrins within the alveolar …

[HTML][HTML] Saliva for COVID-19 testing: Simple but useless or an undervalued resource?

…, C Reffin, I Hill, I Lee, S Wu, J Porte… - Frontiers in …, 2021 - frontiersin.org
During the COVID-19 pandemic, countries with robust population-based asymptomatic testing
were generally successful in controlling virus spread, hence reducing hospitalizations and …

[HTML][HTML] Reduced ets domain-containing protein Elk1 promotes pulmonary fibrosis via increased integrin αvβ6 expression

AL Tatler, A Habgood, J Porte, AE John… - Journal of Biological …, 2016 - ASBMB
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with high mortality.
Active TGFβ1 is considered central to the pathogenesis of IPF. A major mechanism of TGFβ1 …