[PDF][PDF] Organoid modeling of the tumor immune microenvironment
In vitro cancer cultures, including three-dimensional organoids, typically contain exclusively
neoplastic epithelium but require artificial reconstitution to recapitulate the tumor …
neoplastic epithelium but require artificial reconstitution to recapitulate the tumor …
[HTML][HTML] Progenitor identification and SARS-CoV-2 infection in human distal lung organoids
The distal lung contains terminal bronchioles and alveoli that facilitate gas exchange. Three-dimensional
in vitro human distal lung culture systems would strongly facilitate the …
in vitro human distal lung culture systems would strongly facilitate the …
Poly (ADP-ribose) polymerase-1 is a determining factor in Crm1-mediated nuclear export and retention of p65 NF-κB upon TLR4 stimulation
The role of NF-κB in the expression of inflammatory genes and its participation in the overall
inflammatory process of chronic diseases and acute tissue injury are well established. We …
inflammatory process of chronic diseases and acute tissue injury are well established. We …
[HTML][HTML] NADPH oxidase deficiency underlies dysfunction of aged CD8+ Tregs
Z Wen, Y Shimojima, T Shirai, Y Li, J Ju… - The Journal of …, 2016 - Am Soc Clin Investig
Immune aging results in progressive loss of both protective immunity and T cell–mediated
suppression, thereby conferring susceptibility to a combination of immunodeficiency and …
suppression, thereby conferring susceptibility to a combination of immunodeficiency and …
[PDF][PDF] Deficient activity of the nuclease MRE11A induces T cell aging and promotes arthritogenic effector functions in patients with rheumatoid arthritis
Y Li, Y Shen, P Hohensinner, J Ju, Z Wen… - Immunity, 2016 - cell.com
Immune aging manifests with a combination of failing adaptive immunity and insufficiently
restrained inflammation. In patients with rheumatoid arthritis (RA), T cell aging occurs …
restrained inflammation. In patients with rheumatoid arthritis (RA), T cell aging occurs …
[HTML][HTML] Apoptotic DNA fragmentation may be a cooperative activity between caspase-activated deoxyribonuclease and the poly (ADP-ribose) polymerase-regulated …
Caspase-activated DNase (CAD) is the most favorable candidate for chromatin degradation
during apoptosis. Ca 2+ -dependent endonucleases are equally important in …
during apoptosis. Ca 2+ -dependent endonucleases are equally important in …
Requirement for inducible nitric oxide synthase in chronic allergen exposure-induced pulmonary fibrosis but not inflammation
…, PC Rodriguez, CP Hans, J Ju… - The Journal of …, 2010 - journals.aai.org
The role of inducible NO synthase (iNOS) in allergic airway inflammation remains elusive.
We tested the hypothesis that iNOS plays different roles during acute versus chronic airway …
We tested the hypothesis that iNOS plays different roles during acute versus chronic airway …
Age-associated failure to adjust type I IFN receptor signaling thresholds after T cell activation
G Li, J Ju, CM Weyand, JJ Goronzy - The Journal of Immunology, 2015 - journals.aai.org
With increasing age, naive CD4 T cells acquire intrinsic defects that compromise their ability
to respond and differentiate. Type I IFNs, pervasive constituents of the environment in which …
to respond and differentiate. Type I IFNs, pervasive constituents of the environment in which …
[HTML][HTML] Cordycepin blocks lung injury-associated inflammation and promotes BRCA1-deficient breast cancer cell killing by effectively inhibiting PARP
Cordycepin has been shown to interfere with a myriad of molecular processes from RNA
elongation to kinase activity, and prevents numerous inflammatory processes in animal models. …
elongation to kinase activity, and prevents numerous inflammatory processes in animal models. …
[HTML][HTML] High-fat diet induces lung remodeling in ApoE-deficient mice: an association with an increase in circulatory and lung inflammatory factors
Hypercholesterolemia is increasingly considered the basis for not only cardiovascular
pathologies but also several complications affecting other organs such as lungs. In this study, we …
pathologies but also several complications affecting other organs such as lungs. In this study, we …