Identification of seven loci affecting mean telomere length and their association with disease

…, E Albrecht, M Mangino, J Deelen, JL Buxton… - Nature …, 2013 - nature.com
Interindividual variation in mean leukocyte telomere length (LTL) is associated with cancer
and several age-associated diseases. We report here a genome-wide meta-analysis of …

Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis

…, A Pouta, J Pekkanen, AIF Blakemore, JL Buxton… - Nature …, 2012 - nature.com
Atopic dermatitis (AD) is a commonly occurring chronic skin disease with high heritability.
Apart from filaggrin (FLG), the genes influencing atopic dermatitis are largely unknown. We …

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

…, AJ Bennett, AIF Blakemore, JL Buxton… - Nature …, 2013 - nature.com
Birth weight within the normal range is associated with a variety of adult-onset diseases, but
the mechanisms behind these associations are poorly understood 1 . Previous genome-…

Childhood obesity is associated with shorter leukocyte telomere length

JL Buxton, RG Walters, S Visvikis-Siest… - The Journal of …, 2011 - academic.oup.com
Context: Obesity in adults is associated with shorter mean leukocyte telomere length (LTL),
a marker of biological age that is also associated with age-related conditions including …

[PDF][PDF] Genome-wide association analysis in humans links nucleotide metabolism to leukocyte telomere length

…, A Allione, PP Arp, L Broer, JL Buxton… - The American Journal of …, 2020 - cell.com
Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we
perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed …

Common variants at 12q15 and 12q24 are associated with infant head circumference

…, MA Ikram, LJ Beilin, K Bønnelykke, JL Buxton… - Nature …, 2012 - nature.com
To identify genetic variants associated with head circumference in infancy, we performed a
meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of …

A novel common variant in DCST2 is associated with length in early life and height in adulthood

…, AI Blakemore, JL Buxton… - Human molecular …, 2015 - academic.oup.com
Common genetic variants have been identified for adult height, but not much is known
about the genetics of skeletal growth in early life. To identify common genetic variants that …

Telomere length in circulating leukocytes is associated with lung function and disease

…, JL Buxton, CP Nelson, L Broer… - European …, 2014 - Eur Respiratory Soc
Several clinical studies suggest the involvement of premature ageing processes in chronic
obstructive pulmonary disease (COPD). Using an epidemiological approach, we studied …

GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI

…, GD Smith, P O'Reilly, JF Felix, JL Buxton… - Science …, 2019 - science.org
Early childhood growth patterns are associated with adult health, yet the genetic factors and
the developmental stages involved are not fully understood. Here, we combine genome-…

[HTML][HTML] Truncating Homozygous Mutation of Carboxypeptidase E (CPE) in a Morbidly Obese Female with Type 2 Diabetes Mellitus, Intellectual Disability and …

SIM Alsters, AP Goldstone, JL Buxton, A Zekavati… - PloS one, 2015 - journals.plos.org
Carboxypeptidase E is a peptide processing enzyme, involved in cleaving numerous
peptide precursors, including neuropeptides and hormones involved in appetite control and …