Identification of seven loci affecting mean telomere length and their association with disease
Interindividual variation in mean leukocyte telomere length (LTL) is associated with cancer
and several age-associated diseases. We report here a genome-wide meta-analysis of …
and several age-associated diseases. We report here a genome-wide meta-analysis of …
Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis
…, A Pouta, J Pekkanen, AIF Blakemore, JL Buxton… - Nature …, 2012 - nature.com
Atopic dermatitis (AD) is a commonly occurring chronic skin disease with high heritability.
Apart from filaggrin (FLG), the genes influencing atopic dermatitis are largely unknown. We …
Apart from filaggrin (FLG), the genes influencing atopic dermatitis are largely unknown. We …
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism
…, AJ Bennett, AIF Blakemore, JL Buxton… - Nature …, 2013 - nature.com
Birth weight within the normal range is associated with a variety of adult-onset diseases, but
the mechanisms behind these associations are poorly understood 1 . Previous genome-…
the mechanisms behind these associations are poorly understood 1 . Previous genome-…
Childhood obesity is associated with shorter leukocyte telomere length
JL Buxton, RG Walters, S Visvikis-Siest… - The Journal of …, 2011 - academic.oup.com
Context: Obesity in adults is associated with shorter mean leukocyte telomere length (LTL),
a marker of biological age that is also associated with age-related conditions including …
a marker of biological age that is also associated with age-related conditions including …
[PDF][PDF] Genome-wide association analysis in humans links nucleotide metabolism to leukocyte telomere length
…, A Allione, PP Arp, L Broer, JL Buxton… - The American Journal of …, 2020 - cell.com
Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we
perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed …
perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed …
Common variants at 12q15 and 12q24 are associated with infant head circumference
To identify genetic variants associated with head circumference in infancy, we performed a
meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of …
meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of …
A novel common variant in DCST2 is associated with length in early life and height in adulthood
…, AI Blakemore, JL Buxton… - Human molecular …, 2015 - academic.oup.com
Common genetic variants have been identified for adult height, but not much is known
about the genetics of skeletal growth in early life. To identify common genetic variants that …
about the genetics of skeletal growth in early life. To identify common genetic variants that …
Telomere length in circulating leukocytes is associated with lung function and disease
Several clinical studies suggest the involvement of premature ageing processes in chronic
obstructive pulmonary disease (COPD). Using an epidemiological approach, we studied …
obstructive pulmonary disease (COPD). Using an epidemiological approach, we studied …
GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI
Early childhood growth patterns are associated with adult health, yet the genetic factors and
the developmental stages involved are not fully understood. Here, we combine genome-…
the developmental stages involved are not fully understood. Here, we combine genome-…
[HTML][HTML] Truncating Homozygous Mutation of Carboxypeptidase E (CPE) in a Morbidly Obese Female with Type 2 Diabetes Mellitus, Intellectual Disability and …
SIM Alsters, AP Goldstone, JL Buxton, A Zekavati… - PloS one, 2015 - journals.plos.org
Carboxypeptidase E is a peptide processing enzyme, involved in cleaving numerous
peptide precursors, including neuropeptides and hormones involved in appetite control and …
peptide precursors, including neuropeptides and hormones involved in appetite control and …