Importance Severely injured patients experiencing hemorrhagic shock often require massive
transfusion. Earlier transfusion with higher blood product ratios (plasma, platelets, and red …

We have shown that the integrin αvβ6 activates latent TGF-β in the lungs and skin. We show
here that mice lacking this integrin are completely protected from pulmonary edema in a …

Background No single pulmonary-specific variable, including the severity of hypoxemia, has
been found to predict the risk of death independently when measured early in the course of …

Objectives: Coagulopathy following major trauma is conventionally attributed to activation and
consumption of coagulation factors. Recent studies have identified an acute coagulopathy …

Background: Coagulopathy is present at admission in 25% of trauma patients, is associated
with shock and a 5-fold increase in mortality. The coagulopathy has recently been …

Background: Recent studies have identified an acute traumatic coagulopathy that is present
on admission to the hospital and is independent of iatrogenic causes. We have previously …

Objectives To estimate the frequency of acute withdrawal syndrome related to the
administration of analgesic and sedative medications in mechanically ventilated adult …

Although neutrophil extracellular traps (NETs) form to prevent dissemination of pathogenic
microorganisms, excessive release of DNA and DNA-associated proteins can also …

Objective: The purpose of this study was to determine the incidence of acute lung injury (ALI)
in trauma patients with severe traumatic brain injury (TBI), to evaluate the impact of ALI on …

The prevention of DIC in septic patients is a key therapeutic target in preventing death from
multisystem organ failure. Stratifying patients for therapy using thromboelastometry, specific …