Cystic fibrosis (CF) is a life-limiting disease characterised by recurrent respiratory infections,
inflammation and lung damage. The volume and composition of the airway surface liquid (…

The nasal epithelium is a plausible entry point for SARS-CoV-2, a site of pathogenesis and
transmission, and may initiate the host response to SARS-CoV-2. Antiviral interferon (IFN) …

Background Diabetes is a risk factor for respiratory infection, and hyperglycaemia is
associated with increased glucose in airway surface liquid and risk of Staphylococcus aureus …

In most HCO 3 − -secreting epithelial tissues, SLC26 Cl − /HCO 3 − transporters work in
concert with the cystic fibrosis transmembrane conductance regulator (CFTR) to regulate the …

Diabetes is associated with increased frequency of hospitalization due to bacterial lung
infection. We hypothesize that increased airway glucose caused by hyperglycaemia leads to …

For over 50 years, glucose has been recognised to cross the lung epithelial barrier and be
transported by lung epithelial cells. However, until recently, research into these processes …

The glucose concentration of the airway surface liquid (ASL) is much lower than that in blood
and is tightly regulated by the airway epithelium. ASL glucose is elevated in patients with …

Idiopathic pulmonary fibrosis (IPF) is a fatal disease of unknown cause that is characterized
by progressive fibrotic lung remodeling. An abnormal emergence of airway epithelial‐like …

In order to circumvent the limited access and donor variability of human primary alveolar
cells, directed differentiation of human pluripotent stem cells (hiPSCs) into alveolar-like cells, …

People with cystic fibrosis (CF) who develop related diabetes (CFRD) have accelerated
pulmonary decline, increased infection with antibiotic-resistant Pseudomonas aeruginosa and …