User profiles for J. W. Upham

John Upham

Professor of Respiratory Medicine, The University of Queensland
Verified email at uq.edu.au
Cited by 11457

Contemporaneous maturation of immunologic and respiratory functions during early childhood: implications for development of asthma prevention strategies

PG Holt, JW Upham, PD Sly - Journal of Allergy and Clinical Immunology, 2005 - Elsevier
The term asthma refers to a spectrum of wheezing syndromes resulting from airways
inflammation triggered by a range of environmental stimuli, the most important of which are …

Protracted bacterial bronchitis: the last decade and the road ahead

AB Chang, JW Upham, IB Masters… - Pediatric …, 2016 - Wiley Online Library
Cough is the single most common reason for primary care physician visits and, when chronic,
a frequent indication for specialist referrals. In children, a chronic cough (>4 weeks) is …

Rational oral corticosteroid use in adult severe asthma: a narrative review

LP Chung, JW Upham, PG Bardin, M Hew - Respirology, 2020 - Wiley Online Library
OCS play an important role in the management of asthma. However, steroid‐related AE are
common and represent a leading cause of morbidity. Limited published studies suggest …

Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): a randomised, double-blind, placebo …

PG Gibson, IA Yang, JW Upham, PN Reynolds… - The Lancet, 2017 - thelancet.com
Background Exacerbations of asthma cause a substantial global illness burden. Adults with
uncontrolled persistent asthma despite maintenance treatment require additional therapy. …

[HTML][HTML] Inflammatory phenotypes in patients with severe asthma are associated with distinct airway microbiology

…, JM Choo, S Wesselingh, IA Yang, JW Upham… - Journal of Allergy and …, 2018 - Elsevier
Background Asthma pathophysiology and treatment responsiveness are predicted by
inflammatory phenotype. However, the relationship between airway microbiology and asthma …

Development of interleukin-12-producing capacity throughout childhood

JW Upham, PT Lee, BJ Holt, T Heaton… - Infection and …, 2002 - Am Soc Microbiol
Increasing evidence indicates that the capacity to induce protective Th1 immune responses
is impaired in early childhood, an observation that can be partially attributed to deficiencies …

Full blood count parameters for the detection of asthma inflammatory phenotypes

…, H Powell, IA Yang, JW Upham… - Clinical & …, 2014 - Wiley Online Library
Background In asthma, the airway inflammatory phenotype influences clinical characteristics
and treatment response. Although induced sputum is the gold standard test for phenotyping …

Rapid dendritic cell recruitment to the bronchial mucosa of patients with atopic asthma in response to local allergen challenge

FL Jahnsen, ED Moloney, T Hogan, JW Upham… - Thorax, 2001 - thorax.bmj.com
BACKGROUND Airway dendritic cells (DC) play an important role in chronic allergic airway
inflammation in experimental animals, but a similar role for DC in human allergic asthma has …

Airway dysbiosis: Haemophilus influenzae and Tropheryma in poorly controlled asthma

…, J Daly, KJ Baines, IA Yang, JW Upham… - European …, 2016 - Eur Respiratory Soc
Asthma is a chronic inflammatory disorder of the airways where bacteria may act as protagonists
of chronic inflammation. Little is known about the relation of airway inflammation to the …

Treatable traits can be identified in a severe asthma registry and predict future exacerbations

…, M Peters, PG Bardin, PN Reynolds, JW Upham… - …, 2019 - Wiley Online Library
Background and objective A new taxonomic and management approach, termed treatable
traits, has been proposed for airway diseases including severe asthma. This study examined …