User profiles for J. Valadas

Jorge S. Valadas

Muna Therapeutics
Verified email at munatherapeutics.com
Cited by 677

Therapeutic strategies in Parkinson's disease: what we have learned from animal models

JS Valadas, M Vos, P Verstreken - … of the New York Academy of …, 2015 - Wiley Online Library
Therapeutic strategies in Parkinson's disease: what we have learned from animal models -
Valadas - 2015 - Annals of the New York Academy of Sciences - Wiley Online Library …

Adenosine A2A receptor blockade reverts hippocampal stress-induced deficits and restores corticosterone circadian oscillation

…, JM Pêgo, BM Fontinha, AR Costenla, JS Valadas… - Molecular …, 2013 - nature.com
… Optical density was determined with Image-J software and normalized to the respective β-…
Lehmann J, Stohr T, Feldon J . Long-term effects of prenatal stress experiences and postnatal …

Tiotropium inhibits pulmonary inflammation and remodelling in a guinea pig model of COPD

T Pera, A Zuidhof, J Valadas, M Smit… - European …, 2011 - Eur Respiratory Soc
Airway remodelling and emphysema are major structural abnormalities in chronic obstructive
pulmonary disease (COPD). In addition, pulmonary vascular remodelling may occur and …

[HTML][HTML] Overexpression of Adenosine A2A Receptors in Rats: Effects on Depression, Locomotion, and Anxiety

JE Coelho, P Alves, PM Canas, JS Valadas… - Frontiers in …, 2014 - frontiersin.org
Valadas Jorge S. Valadas 1 \r\n Tatiana Shmidt Tatiana Shmidt 5 \r\n V nia L. Batalha Vânia
L. … The authors acknowledge J. Baião for technical assistance in the animal house. Joana E. …

[PDF][PDF] ER lipid defects in neuropeptidergic neurons impair sleep patterns in Parkinson's disease

JS Valadas, G Esposito, D Vandekerkhove… - Neuron, 2018 - cell.com
… (G–J) Quantification of the number of brief awakenings in a 24-hr period (G) and the number
… activity plots of individual flies (rows; I and J). Each vertical bar represents an active minute. …

[HTML][HTML] The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function

VL Batalha, DG Ferreira, JE Coelho, JS Valadas… - Scientific Reports, 2016 - nature.com
… Optical density was determined with Image-J software. … Cell treatments were performed as
in Valadas 24 . Drug treatments were vehicle matched to drugs, with a max DMSO of 0.001%. …

Propiconazole induces abnormal behavior and oxidative stress in zebrafish

J Valadas, R Mocelin, A Sachett, M Marcon… - … Science and Pollution …, 2019 - Springer
The use of pesticides has been growing along with the demand for agricultural products.
These compounds, however, are not restricted to the field, spreading easily through the soil, …

Escitalopram improves memory deficits induced by maternal separation in the rat

…, VL Batalha, JS Valadas, J Data-Franca… - European journal of …, 2012 - Elsevier
Maternal separation (MS) induces depressive-like behavior and long-term changes in
cognition in rats. Escitalopram is an antidepressant drug shown to reverse the depressive-like …

[HTML][HTML] HDAC6 is a Bruchpilot deacetylase that facilitates neurotransmitter release

…, LE Jose, WM Yeshaw, JS Valadas, J Swerts… - Cell Reports, 2014 - cell.com
… (H–J) Releasable vesicle fusion measured as the mean relative synaptopHluorin (SpH)
fluorescence change (ΔF/Fo) during a 60 Hz 50 action potential train (black line). The average …

O impacto do ciclo de exploração na rentabilidade das empresas portuguesas: um estudo empírico

JCM Valadas - 2005 - repository.utl.pt
O objectivo do presente trabalho consiste em estudar, de forma empírica, a existência de
uma eventual relação inversa entre necessidades de fundo de maneio, medida pelo ciclo …