Hepatotoxicity of antibacterials: pathomechanisms and clinical data
JM Leitner, W Graninger, F Thalhammer - Infection, 2010 - Springer
Drug-induced hepatotoxicity is a frequent cause of liverdisease and acute liver failure,
particularly in patients treatedwith multiple drugs. Several antibacterial drugs have thepotential to …
particularly in patients treatedwith multiple drugs. Several antibacterial drugs have thepotential to …
Platelet function predicts myocardial damage in patients with acute myocardial infarction
M Frossard, I Fuchs, JM Leitner, K Hsieh, M Vlcek… - Circulation, 2004 - Am Heart Assoc
Background— Platelet activation is a hallmark of acute coronary syndromes. Numerous
lines of evidence suggest a mechanistic link between von Willebrand factor or platelet …
lines of evidence suggest a mechanistic link between von Willebrand factor or platelet …
Duffy antigen modifies the chemokine response in human endotoxemia
FB Mayr, AO Spiel, JM Leitner, C Firbas… - Critical care …, 2008 - journals.lww.com
Objective: The Duffy receptor is a promiscuous receptor for chemokines and selectively
binds CXC and CC chemokines with high affinity. Preclinical data show that presence of the …
binds CXC and CC chemokines with high affinity. Preclinical data show that presence of the …
[HTML][HTML] Massive pulmonary embolism leading to cardiac arrest is associated with consumptive coagulopathy presenting as disseminated intravascular coagulation
JM Leitner, B Jilma, AO Spiel, F Sterz… - Journal of Thrombosis …, 2010 - Elsevier
See also Levi M. Disseminated intravascular coagulation or extended intravascular coagulation
in massive pulmonary embolism. This issue, pp 1475–6; Thachil J. DIC score predicts …
in massive pulmonary embolism. This issue, pp 1475–6; Thachil J. DIC score predicts …
Recombinant human antithrombin inhibits thrombin formation and interleukin 6 release in human endotoxemia
JM Leitner, C Firbas, FB Mayr, RA Reiter… - Clinical …, 2006 - Wiley Online Library
We hypothesized that infusion of recombinant human antithrombin without concomitant
heparin would have dose‐dependent anticoagulant properties and potentially decrease …
heparin would have dose‐dependent anticoagulant properties and potentially decrease …
Ethnic differences in plasma levels of interleukin-8 (IL-8) and granulocyte colony stimulating factor (G-CSF)
FB Mayr, AO Spiel, JM Leitner, C Firbas, T Kliegel… - Translational …, 2007 - Elsevier
Ethnic neutropenia is common in people of African descent. As interleukin-8 (IL-8) and
granulocyte colony stimulating factor (G-CSF) bind to receptors on neutrophils, ethnic differences …
granulocyte colony stimulating factor (G-CSF) bind to receptors on neutrophils, ethnic differences …
Effects of low dose endotoxemia on endothelial progenitor cells in humans
FB Mayr, AO Spiel, JM Leitner, C Firbas, W Sieghart… - Atherosclerosis, 2007 - Elsevier
BACKGROUND: Endothelial progenitor cells (EPCs) are a specific subtype of hematopoietic
stem cells that migrate from the bone marrow to the peripheral circulation where they …
stem cells that migrate from the bone marrow to the peripheral circulation where they …
[HTML][HTML] Racial differences in endotoxin-induced tissue factor-triggered coagulation
FB Mayr, AO Spiel, JM Leitner, C Firbas… - Journal of Thrombosis …, 2009 - Elsevier
Background: Racial differences in coagulation are poorly understood. While some studies
suggest a ‘prothrombotic’ coagulation profile in blacks compared with whites, others report an …
suggest a ‘prothrombotic’ coagulation profile in blacks compared with whites, others report an …
Simvastatin and rosuvastatin mobilize Endothelial Progenitor Cells but do not prevent their acute decrease during systemic inflammation
AO Spiel, FB Mayr, JM Leitner, C Firbas, W Sieghart… - Thrombosis …, 2008 - Elsevier
INTRODUCTION: Endothelial Progenitor Cells (EPCs) are a specific subtype of haematopoietic
stem cells that contribute to the repair of injured endothelium. Treatment with atorvastatin …
stem cells that contribute to the repair of injured endothelium. Treatment with atorvastatin …
Reparixin, a specific interleukin-8 inhibitor, has no effects on inflammation during endotoxemia
JM Leitner, FB Mayr, C Firbas… - International …, 2007 - journals.sagepub.com
Reparixin antagonizes interleukin-8 (IL-8) on the level of signal transduction in vitro. We
hypothesized that IL-8 mediates some of the reactions occurring during acute inflammation and …
hypothesized that IL-8 mediates some of the reactions occurring during acute inflammation and …