Asthma outcomes: biomarkers

…, SC Erzurum, JV Fahy, RG Hamilton, JF Hunt… - Journal of Allergy and …, 2012 - Elsevier
BACKGROUND: Measurement of biomarkers has been incorporated within clinical
research studies of asthma to characterize the population and associate the disease with …

[HTML][HTML] ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer

…, L Millen, JE Moody, J Rosen, PJ Thomas, JF Hunt - Molecular cell, 2002 - cell.com
It has been proposed that the reaction cycle of ATP binding cassette (ABC) transporters is
driven by dimerization of their ABC motor domains upon binding ATP at their mutual interface. …

Endogenous airway acidification: implications for asthma pathophysiology

JF HUNT, K Fang, R Malik, A Snyder… - American journal of …, 2000 - atsjournals.org
Airway concentrations of many reactive nitrogen and oxygen species are high in asthma.
The stability and bioactivities of these species are pH-dependent; however, the pH of the …

The crystal structure of the GroES co-chaperonin at 2.8 Ċ resolution

JF Hunt, AJ Weaver, SJ Landry, L Gierasch… - Nature, 1996 - nature.com
The GroES heptamer forms a dome, approximately 75 Ċ in diameter and 30 Ċ high, with an 8
Ċ orifice in the centre of its roof. The 'mobile loop' segment, previously identified as a GroEL …

[HTML][HTML] Glycophorin A dimerization is driven by specific interactions between transmembrane alpha-helices.

MA Lemmon, JM Flanagan, JF Hunt, BD Adair… - Journal of Biological …, 1992 - Elsevier
Specific side-by-side interactions between transmembrane alpha-helices may be important
in the assembly and function of integral membrane proteins. We describe a system for the …

Structure of nucleotide‐binding domain 1 of the cystic fibrosis transmembrane conductance regulator

…, X Gao, WB Guggino, WA Hendrickson, JF Hunt… - The EMBO …, 2004 - embopress.org
Cystic fibrosis transmembrane conductance regulator (CFTR) is an ATP‐binding cassette (ABC)
transporter that functions as a chloride channel. Nucleotide‐binding domain 1 (NBD1), …

Codon influence on protein expression in E. coli correlates with mRNA levels

…, R Xiao, GT Montelione, DP Aalberts, JF Hunt - Nature, 2016 - nature.com
Degeneracy in the genetic code, which enables a single protein to be encoded by a multitude
of synonymous gene sequences, has an important role in regulating protein expression, …

[HTML][HTML] Cooperative, ATP-dependent association of the nucleotide binding cassettes during the catalytic cycle of ATP-binding cassette transporters

JE Moody, L Millen, D Binns, JF Hunt… - Journal of Biological …, 2002 - ASBMB
ATP-binding cassette (ABC) transporters harvest the energy present in cellular ATP to drive
the translocation of a structurally diverse set of solutes across the membrane barriers of …

ATS workshop proceedings: exhaled nitric oxide and nitric oxide oxidative metabolism in exhaled breath condensate

…, SC George, N Marczin, JF Hunt… - Proceedings of the …, 2006 - pubmed.ncbi.nlm.nih.gov
… Philip E Silkoff, Serpil C Erzurum, Jon O Lundberg, Steven C George, Nandor Marczin,
John F Hunt, Richard Effros, Ildiko Horvath; American Thoracic Society; HOC Subcommittee …

Nucleotide control of interdomain interactions in the conformational reaction cycle of SecA

JF Hunt, S Weinkauf, L Henry, JJ Fak, P McNicholas… - Science, 2002 - science.org
The SecA adenosine triphosphatase (ATPase) mediates extrusion of the amino termini of
secreted proteins from the eubacterial cytosol based on cycles of reversible binding to the …