Mechanisms of bronchial hyperreactivity in normal subjects after upper respiratory tract infection

…, LA Laitinen, L Jacobs, WM Gold, JA Nadel - American Review of …, 1976 - atsjournals.org
Inhalation of histamine diphosphate aerosol (1.6 per cent, 10 breaths) produced a 218 ±
54.6 per cent (mean ± SE) increase in airway resistance in 16 normal subjects with colds …

[BOOK][B] Murray and Nadel's textbook of respiratory medicine E-book: 2-volume set

…, TE King, D Schraufnagel, JF Murray, JA Nadel - 2010 - books.google.com
Murray and Nadel’s Textbook of Respiratory Medicine has long been the definitive and
comprehensive pulmonary disease reference. Robert J. Mason, MD now presents the fifth edition …

Epidermal growth factor system regulates mucin production in airways

…, IF Ueki, KM Grattan, JA Nadel - Proceedings of the …, 1999 - National Acad Sciences
Goblet-cell hyperplasia is a critical pathological feature in hypersecretory diseases of airways.
However, the underlying mechanisms are unknown, and no effective therapy exists. Here …

Bronchial hyperreactivity

…, MJ Holtzman, JR Sheller, JA Nadel - American Review of …, 1980 - atsjournals.org
… Hahn HL, Graf PO, Nadel JA. Effect of vagal tone on airway diameters and lung volume
in anesthetized dogs. J Appl Physiol 1976; 41:581-9. … Hahn HL, Nadel JA. Methods of …

IL-4 induces mucin gene expression and goblet cell metaplasia in vitro and in vivo

…, HM Lee, IF Ueki, JA Lausier, JA Nadel - The Journal of …, 1999 - journals.aai.org
Goblet cell metaplasia and mucus hypersecretion are important features in the pathogenesis
of asthma. The cytokine IL-4 has been shown to play a role in animal models of asthma, …

O3-induced change in bronchial reactivity to methacholine and airway inflammation in humans

…, M Stulbarg, MJ Holtzman, JA Nadel… - Journal of Applied …, 1986 - journals.physiology.org
NADEL. Mechanisms of bronchial hyperreactivity in normal subjects following upper …
HOLTZMAN, AND JA NADEL. Indomethacin inhibits the airway hyperresponsiveness but not the …

Effect of a previous deep inspiration on airway resistance in man

JA Nadel, DF Tierney - Journal of applied physiology, 1961 - journals.physiology.org
We measured airway resistance and thoracic gas volume by the body plethysmograph
technique, and transpulmonary pressure in seven healthy, adult subjects, before and after …

Oxidative stress causes mucin synthesis via transactivation of epidermal growth factor receptor: role of neutrophils

…, T Dao-Pick, IF Ueki, JA Nadel - The Journal of …, 2000 - journals.aai.org
Oxidative stress has been implicated in the pathogenesis of inflammatory diseases of airways.
Here we show that oxidative stress causes ligand-independent activation of epidermal …

Interleukin-8: an important chemoattractant in sputum of patients with chronic inflammatory airway diseases

…, CA Hebert, I Ueki, JA Nadel - … of Physiology-Lung …, 1993 - journals.physiology.org
Sputum from patients with cystic fibrosis, bronchiectasis, and chronic bronchitis contains
neutrophils and neutrophil proteases, which have been implicated in the pathophysiology of …

Neutrophil elastase and cathepsin G stimulate secretion from cultured bovine airway gland serous cells.

CP Sommerhoff, JA Nadel… - The Journal of …, 1990 - Am Soc Clin Investig
To investigate the hypothesis that neutrophil proteases stimulate airway gland secretion, we
studied the effect of human cathepsin G and elastase on secretion of 35S-labeled …