Epigenomic studies aim to define the location and nature of the genomic sequences that are
epigenetically modified. Much progress has been made towards whole-genome epigenetic …

Epigenome-wide association studies (EWAS) hold promise for the detection of new regulatory
mechanisms that may be susceptible to modification by environmental and lifestyle factors …

Epigenetic association studies have been carried out to test the hypothesis that environmental
perturbations trigger cellular reprogramming, with downstream effects on cellular function …

The incorporation of histone H3 variants has been implicated in the epigenetic memory of
cellular state. Using genome editing with zinc-finger nucleases to tag endogenous H3.3, we …

We hypothesized that DNA methylation distributes into specific patterns in cancer cells, which
reflect critical biological differences. We therefore examined the methylation profiles of 344 …

We report a high-quality draft of the genome sequence of the grey, short-tailed opossum (Monodelphis
domestica). As the first metatherian (‘marsupial’) species to be sequenced, the …

The distribution of cytosine methylation in 6.2 Mb of the mouse genome was tested using
cohybridization of genomic representations from a methylation-sensitive restriction enzyme and …

During X chromosome inactivation (XCI), Xist RNA coats and silences one of the two X
chromosomes in female cells. Little is known about how XCI spreads across the chromosome, …

Increasing evidence shows aberrant hypermethylation of genes occurring in and potentially
contributing to pathogenesis of myeloid malignancies. Several of these diseases, such as …

Antibody specificity and diversity is generated in B cells during germinal center maturation
through clonal expansion while they undergo class-switch recombination and somatic …