User profiles for J Gauldie

Jack Gauldie

Professor of Pathology and Molecular Medicine, McMaster University
Verified email at mcmaster.ca
Cited by 50066

The acute phase response

H Baumann, J Gauldie - Immunology today, 1994 - Elsevier
Adult mammals respond to tissue damage by implementing the acute phase response, which
comprises a series of specific physiological reactions. This review outlines the principal …

The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis?

A Moeller, K Ask, D Warburton, J Gauldie… - The international journal …, 2008 - Elsevier
Different animal models of pulmonary fibrosis have been developed to investigate potential
therapies for idiopathic pulmonary fibrosis (IPF). The most common is the bleomycin model …

Regulation of hepatic acute phase plasma protein genes by hepatocyte stimulating factors and other mediators of inflammation.

H Baumann, J Gauldie - Molecular biology & medicine, 1990 - europepmc.org
The hepatic response to systemic injury is characterized by a co-ordinated increase in the
expression of several, functionally essential plasma proteins. The factors responsible for initial …

Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein …

J Gauldie, C Richards, D Harnish… - Proceedings of the …, 1987 - National Acad Sciences
One of the oldest and most preserved of the homeostatic responses of the body to injury is
the acute phase protein response associated with inflammation. The liver responds to …

IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses.

Z Xing, J Gauldie, G Cox, H Baumann… - The Journal of …, 1998 - Am Soc Clin Investig
Gauldie. 1997. Adenoviral vector–mediated interleukin-10 expression in vivo: intramuscular
… Shoyab, TJ Brown, and J. Gauldie. 1993. Selective regulation of metalloproteinase inhibitor (…

Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung.

…, FL Graham, KG Csaky, J Gauldie - The Journal of …, 1997 - Am Soc Clin Investig
Transforming growth factor (TGF)-beta1 has been implicated in the pathogenesis of fibrosis
based upon its matrix-inducing effects on stromal cells in vitro, and studies demonstrating …

[HTML][HTML] Transient expression of IL-1β induces acute lung injury and chronic repair leading to pulmonary fibrosis

…, DC Anthony, F Pitossi, J Gauldie - The Journal of …, 2001 - Am Soc Clin Investig
IL-1β is one of a family of proinflammatory cytokines thought to be involved in many acute
and chronic diseases. Although it is considered to participate in wound repair, no major role …

Circulating fibrocytes are an indicator of poor prognosis in idiopathic pulmonary fibrosis

…, K Ask, G Cox, D Cook, J Gauldie… - American journal of …, 2009 - atsjournals.org
Rationale: The clinical management of idiopathic pulmonary fibrosis (IPF) remains a major
challenge due to lack of effective drug therapy or accurate indicators for disease progression. …

Regulation of transforming growth factor-β1–driven lung fibrosis by galectin-3

…, SJ Forbes, N Hirani, J Gauldie… - American journal of …, 2012 - atsjournals.org
Rationale: Idiopathic pulmonary fibrosis (IPF) is a chronic dysregulated response to alveolar
epithelial injury with differentiation of epithelial cells and fibroblasts into matrix-secreting …

[HTML][HTML] Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell–induced apoptosis

…, I Shostak, T Sawchuk, CFB Holmes, J Gauldie… - Cell, 2000 - cell.com
The serine proteinase granzyme B is crucial for the rapid induction of target cell apoptosis
by cytotoxic T cells. Granzyme B was recently demonstrated to enter cells in a perforin-…