Methods Clinical practice guidelines for TDM of VCM were reviewed by a practice guideline
committee that consisted of 18 experts in TDM convened from the JSC and the JSTDM. The …

Voriconazole (VRCZ) is a triazole antifungal developed for the treatment of fungal infectious
disease and is available for both oral and intravenous administration. It has potent activity …

The 1st edition of Japanese domestic guidelines for management of deep-seated mycosis
was originally published in 2003, followed by 2nd edition in 2007. Subsequently, the “…

Background: We analyzed the pharmacokinetic-pharmacodynamic relationship of
vancomycin to determine the drug exposure parameters that correlate with the efficacy and …

We investigated the possible presence of DNA specific for Aspergillus species in serum
samples of patients with invasive aspergillosis (IA) by the nested PCR method. Fourteen strains …

Dengue epidemics increasingly pose a public health problem in most countries of the tropical
and subtropical areas. Despite decades of research, development of a safe and effective …

Background Therapeutic drug monitoring (TDM) of voriconazole is important to optimize
efficacy and to minimize toxicity and intolerance. In this study, we evaluated the effect of …

Background The incidence of ocular candidiasis (OC) in patients with candidemia varies
across different reports, and the issue of whether routine ophthalmoscopy improves outcomes …

Studies conducted some 50 years ago showed that serial intracerebral passage of dengue
viruses in mice selected for neurovirulent mutants that also exhibited significant attenuation …

There are several mechanisms for antibiotic-resistant Pseudomonas aeruginosa. The
purpose of this study is to investigate the association between the expression of efflux pump-…