Transforming growth factor-β (TGF-β) is extensively involved in the development of fibrosis in
different organs. Overproduction or potentiation of its profibrotic effects leads to an aberrant …

Pulmonary fibrosis, particularly idiopathic pulmonary fibrosis, represents a chronic and
progressive disease with high mortality and limited therapeutic options. Excessive deposition of …

Background Cigarette smoking is associated with emphysema and radiographic interstitial
lung abnormalities. The degree to which interstitial lung abnormalities are associated with …

Aging promotes lung function decline and susceptibility to chronic lung diseases, which are
the third leading cause of death worldwide. Here, we use single cell transcriptomics and …

Idiopathic pulmonary fibrosis is a serious and progressive chronic lung disease that is
characterised by altered cellular composition and homoeostasis in the peripheral lung, leading to …

Importance Interstitial lung abnormalities have been associated with lower 6-minute walk
distance, diffusion capacity for carbon monoxide, and total lung capacity. However, to our …

The extracellular matrix ( ECM ) is a key regulator of tissue morphogenesis and repair.
However, its composition and architecture are not well characterized. Here, we monitor …

Rationale: The role of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins)
in the development or progression of interstitial lung disease (ILD) is controversial. Objectives…

Rationale: The relationship between interstitial lung abnormalities (ILA) and exercise
capacity has not been comprehensively evaluated. Objectives: To assess the validity of the 6-…

Rationale: Increased abundance and stiffness of the extracellular matrix, in particular
collagens, is a hallmark of idiopathic pulmonary fibrosis (IPF). FK506-binding protein 10 (FKBP10) …