User profiles for Isabelle Roland
Isabelle RolandResearch Economist, Bank of England Verified email at bankofengland.co.uk Cited by 339 |
[HTML][HTML] ERK activation upon hypoxia: involvement in HIF-1 activation
Hypoxia-inducible factor-1 (HIF-1) is a transcription factor activated by hypoxia. The HIF-1
activation transduction pathway is poorly understood. In this report, we investigated the …
activation transduction pathway is poorly understood. In this report, we investigated the …
[HTML][HTML] Hypoxia-induced activation of HIF-1: role of HIF-1α-Hsp90 interaction
The protein chaperone heat shock protein 90 (Hsp90) is a major regulator of different
transcription factors such as MyoD, a basic helix loop helix (bHLH) protein, and the bHLH-Per-aryl …
transcription factors such as MyoD, a basic helix loop helix (bHLH) protein, and the bHLH-Per-aryl …
Systematic characterization of oil-in-water emulsions for formulation design
Oil-in-water emulsions varying in surfactant concentration and manufacturing process were
prepared. About 10 experiments were performed to characterize them. The goal of this …
prepared. About 10 experiments were performed to characterize them. The goal of this …
The α1 subunit of the sodium pump could represent a novel target to combat non‐small cell lung cancers
T Mijatovic, I Roland, E Van Quaquebeke… - The Journal of …, 2007 - Wiley Online Library
With an overall 5 year survival rate as low as 15% for non‐small cell lung cancer (NSCLC),
even with surgical intervention and the use of newer molecules in adjuvant chemotherapy, …
even with surgical intervention and the use of newer molecules in adjuvant chemotherapy, …
The Amaryllidaceae isocarbostyril narciclasine induces apoptosis by activation of the death receptor and/or mitochondrial pathways in cancer cells but not in normal …
…, S Rouzeau, F Ribaucour, S Thomas, I Roland… - Neoplasia, 2007 - Elsevier
Our study has shown that the Amaryllidaceae isocarbostyril narciclasine induces marked
apoptosismediated cytotoxic effects in human cancer cells but not in normal fibroblasts by …
apoptosismediated cytotoxic effects in human cancer cells but not in normal fibroblasts by …
When does leverage hurt productivity growth? A firm-level analysis
In the wake of the global financial crisis, several macroeconomic contributions have
highlighted the risks of excessive credit expansion. In particular, too much finance can have a …
highlighted the risks of excessive credit expansion. In particular, too much finance can have a …
Targeting the α 1 subunit of the sodium pump to combat glioblastoma cells
…, T Mijatovic, Y Kondo, S Sauvage, I Roland… - …, 2008 - journals.lww.com
OBJECTIVE: Ion transporters play pivotal roles in cancer cell migration in general and in
glioblastomas (GBMs) in particular. However, the specific role of Na+/K+-ATPase (the sodium …
glioblastomas (GBMs) in particular. However, the specific role of Na+/K+-ATPase (the sodium …
Disabled-2 is essential for endodermal cell positioning and structure formation during mouse embryogenesis
DH Yang, ER Smith, IH Roland, Z Sheng, J He… - Developmental …, 2002 - Elsevier
The signal transduction adapter protein Disabled-2 (Dab2) is one of the two mammalian
orthologs of the Drosophila Disabled. The brain-specific Disabled-1 (Dab1) functions in …
orthologs of the Drosophila Disabled. The brain-specific Disabled-1 (Dab1) functions in …
HIF1A gene transcription is dependent on a core promoter sequence encompassing activating and inhibiting sequences located upstream from the transcription …
E Minet, I Ernest, G Michel, I Roland, J Remacle… - Biochemical and …, 1999 - Elsevier
Hypoxia inducible factor-1 (HIF-1) is a transcription factor composed of two subunits, HIF-1α
and ARNT, which is activated under hypoxia. HIF-1α mRNA is expressed constitutively in a …
and ARNT, which is activated under hypoxia. HIF-1α mRNA is expressed constitutively in a …
[HTML][HTML] Galectin-1 knockdown increases sensitivity to temozolomide in a B16F10 mouse metastatic melanoma model
…, N De Neve, S Sauvage, T Gras, I Roland… - Journal of Investigative …, 2007 - Elsevier
The rapid increase in the incidence of malignant melanomas has not been associated with
improved therapeutic options over the years. Indeed melanomas have proven resistant to …
improved therapeutic options over the years. Indeed melanomas have proven resistant to …