Standardized single‐platform assay for human monocyte subpopulations: Lower CD14+CD16++ monocytes in females

I Heimbeck, TPJ Hofer, C Eder, AK Wright… - Cytometry Part …, 2010 - Wiley Online Library
We present a novel single‐platform assay for determination of the absolute number of
human blood monocyte subpopulations, ie, the CD14 ++ CD16 − and the CD14 + CD16 ++ …

Emphysema-and airway-dominant COPD phenotypes defined by standardised quantitative computed tomography

…, SJ Vom Silberberg, I Heimbeck… - European …, 2016 - Eur Respiratory Soc
EvA (Emphysema versus Airway disease) is a multicentre project to study mechanisms and
identify biomarkers of emphysema and airway disease in chronic obstructive pulmonary …

[HTML][HTML] Chemokine expression by small sputum macrophages in COPD

M Frankenberger, C Eder, TPJ Hofer, I Heimbeck… - Molecular …, 2011 - Springer
Small sputum macrophages represent highly active cells that Increase In the airways of
patients with Inflammatory diseases such as chronic obstructive pulmonary disease (COPD). It …

[HTML][HTML] Higher bioavailability of magnesium citrate as compared to magnesium oxide shown by evaluation of urinary excretion and serum levels after single-dose …

D Kappeler, I Heimbeck, C Herpich, N Naue, J Höfler… - BMC Nutrition, 2017 - Springer
Background The development of several disorders, such as cardiovascular diseases, diabetes
and osteoporosis, has been linked to suboptimal dietary magnesium (Mg) intake. In this …

[HTML][HTML] Differential inflammatory response to inhaled lipopolysaccharide targeted either to the airways or the alveoli in man

W Möller, I Heimbeck, TPJ Hofer, G Khadem Saba… - PLoS …, 2012 - journals.plos.org
Endotoxin (Lipopolysaccharide, LPS) is a potent inducer of inflammation and there is various
LPS contamination in the environment, being a trigger of lung diseases and exacerbation. …

Epigenetic regulation of vitamin D converting enzymes

M Wjst, I Heimbeck, D Kutschke… - The Journal of steroid …, 2010 - Elsevier
While 25-OH-D3 serum levels in humans undergo a large seasonal variation, 1,25-(OH)2-D3
is regulated within a narrow range. We speculate that in addition to the known genomic …

Decreased expression of HLA-DQ and HLA-DR on cells of the monocytic lineage in cystic fibrosis

TP Hofer, M Frankenberger, I Heimbeck… - Journal of molecular …, 2014 - Springer
We studied HLA class II molecules on blood monocyte subsets, blood dendritic cells, sputum
macrophages, and monocyte-derived macrophages at the protein (flow cytometry) and …

A defect of CD16-positive monocytes can occur without disease

…, MW Angstwurm, H Hoffmann, TPJ Hofer, I Heimbeck… - Immunobiology, 2013 - Elsevier
The CD16-positive monocytes have been first described in 1988 but to date no selective
defect in the number of these cells in blood has been reported. We now describe a family in …

The EvA study: aims and strategy

L Ziegler-Heitbrock, M Frankenberger, I Heimbeck… - 2012 - Eur Respiratory Soc
The EvA study is a European Union-funded project under the Seventh Framework Programme
(FP7), which aims at defining new markers for chronic obstructive pulmonary disease (…

Fractionated exhaled breath condensate collection shows high hydrogen peroxide release in the airways

W Möller, I Heimbeck, N Weber, GK Saba… - Journal of aerosol …, 2010 - liebertpub.com
Background: Exhaled breath condensate (EBC) allows noninvasive monitoring of inflammation
in the lung. Activation of inflammatory cells results in an increased production of reactive …