The human organism coexists with its microbiota in a symbiotic relationship. These
polymicrobial communities are involved in many crucial functions, such as immunity, protection …

Simple Summary Tumor microenvironment is a major contributor to tumor growth, metastasis
and resistance to therapy. It consists of many cancer-associated fibroblasts (CAFs), which …

Background: Chronic constipation is one of the most common disorders in Western countries
and despite numerous clinical, pathophysiologic, and epidemiologic studies its cause is …

Simple Summary Immunotherapy and immune checkpoint inhibitors have become the
breakthrough treatment with extended responses and survival rates in various neoplasms. They …

Background To investigate the predictive significance of KRAS, BRAF, PIK3CA mutational
status, AREG- EREG mRNA expression, PTEN protein expression and skin rash in metastatic …

Background Anemia is an important complication of inflammatory bowel disease (IBD).
Recent data suggest that hepcidin is a major mediator of anemia with a central role in iron …

During the last 35 years, visceral leishmaniasis has spread in Greece with autochthonous
human cases appearing in 41 of the 54 prefectures. The occurrence of the disease was …

Background To prospectively evaluate the usefulness of the BRAFV600E mutation detection
in daily clinical practice in patients with metastatic Colorectal Cancer (mCRC). Patients and …

Background: Circulating tumor cells (CTCs) could escape from the immune system through
the programmed death-ligand 1 (PD-L1)/programmed cell death protein 1 (PD-1) axis …

Simple Summary Kirsten rat sarcoma viral oncogene homolog (KRAS)-mutated colorectal
cancer (CRC) seems to have a different biological behavior and therapeutic approach …