Intracellular functions of N-linked glycans

A Helenius, M Aebi - Science, 2001 - science.org
N-linked oligosaccharides arise when blocks of 14 sugars are added cotranslationally to
newly synthesized polypeptides in the endoplasmic reticulum (ER). These glycans are then …

Endosome maturation

J Huotari, A Helenius - The EMBO journal, 2011 - embopress.org
Being deeply connected to signalling, cell dynamics, growth, regulation, and defence,
endocytic processes are linked to almost all aspects of cell life and disease. In this review, we …

Quality control in the endoplasmic reticulum

L Ellgaard, A Helenius - Nature reviews Molecular cell biology, 2003 - nature.com
The endoplasmic reticulum (ER) has a quality-control system for 'proof-reading' newly
synthesized proteins, so that only native conformers reach their final destinations. Non-native …

Roles of N-linked glycans in the endoplasmic reticulum

A Helenius, M Aebi - Annual review of biochemistry, 2004 - annualreviews.org
▪ Abstract From a process involved in cell wall synthesis in archaea and some bacteria, N-linked
glycosylation has evolved into the most common covalent protein modification in …

Acidification of the endocytic and exocytic pathways

I Mellman, R Fuchs, A Helenius - Annual review of biochemistry, 1986 - annualreviews.org
Most of the membrane organelles in a typical eukaryotic cell belong to the elements of the
exo-and endocytic pathways, referred to collectively as the vacuolar system. They include the …

Solubilization of membranes by detergents

A Helenius, KAI Simons - Biochimica et Biophysica Acta (BBA)-Reviews on …, 1975 - Elsevier
30 membrane structure and function it is usually necessary to dissociate the membrane into
its components. The techniques for extraction and analysis of the membrane lipids are well …

Neuropilin-1 is a host factor for SARS-CoV-2 infection

…, UF Greber, P Horvath, RB Sessions, A Helenius… - Science, 2020 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
coronavirus disease 2019 (COVID-19), uses the viral spike (S) protein for host cell attachment …

Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular-transport pathway to the ER

L Pelkmans, J Kartenbeck, A Helenius - Nature cell biology, 2001 - nature.com
Simian virus 40 (SV40) is unusual among animal viruses in that it enters cells through
caveolae, and the internalized virus accumulates in a smooth endoplasmic reticulum (ER) …

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

…, SJ Butcher, MS Winkler, B Mollenhauer, A Helenius… - Science, 2020 - science.org
The causative agent of coronavirus disease 2019 (COVID-19) is the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). For many viruses, tissue tropism is determined by …

Setting the standards: quality control in the secretory pathway

L Ellgaard, M Molinari, A Helenius - Science, 1999 - science.org
A variety of quality control mechanisms operate in the endoplasmic reticulum and in downstream
compartments of the secretory pathway to ensure the fidelity and regulation of protein …