The mechanisms associated with the development of severe, corticosteroid (CS)-dependent
asthma are poorly understood, but likely heterogenous. It was hypothesized that severe …

Mortality associated with acute lung injury (ALI) induced by lipopolysaccharide (LPS)
remains high in humans, warranting improved treatment and prevention strategies. ALI is …

Background: Asthma is a prevalent disease with marked effects on quality of life and
economic societal burden. However, the cause of asthma and its pathophysiology are not …

IL-23 induces IL-17 production in activated CD4+ T cells and participates in host defense
against many encapsulated bacteria. However, whether the IL-23/IL-17 axis contributes to a …

Short palate, lung, and nasal epithelium clone 1 (SPLUNC1) protein is highly expressed in
normal airways, but is dramatically decreased in allergic and cigarette smoke exposure …

… HONG WEI CHU … HONG WEI CHU … Correspondence and requests for reprints should be
addressed to Hong Wei Chu, MD, National Jewish Medical and Research Center, D202, 1400 …

Background/Objective The use of electronic cigarettes (e-cigarettes) is rapidly increasing in
the United States, especially among young people since e-cigarettes have been perceived …

Distal lung inflammation may be important in asthma pathophysiology. The goal of this
study was to measure cellular inflammation in the large airway and four distal lung regions (small …

Tobacco smoking has been established to contribute to the pathogenesis of various respiratory
diseases including chronic obstructive pulmonary disease (COPD), lung cancer, and …

Carbon nanotubes (CNTs) are carbon based nanomaterials with long hollow structure and
diameter at the nanometer scale. The chirality in combination with the radius determines the …