Background Prophylactic cranial irradiation reduces the incidence of brain metastasis in
patients with small-cell lung cancer. Whether this treatment, when given to patients in complete …

Irinotecan unexpectedly causes severe toxicity of leukopenia or diarrhea. Irinotecan is
metabolized to form active SN-38, which is further conjugated and detoxified by UDP-…

Purpose: Recent studies reported that clinical responsiveness to gefitinib was associated with
somatic mutation of epidermal growth factor receptor (EGFR) gene in non–small cell lung …

Purpose It remains undetermined whether cisplatin and carboplatin are equally effective for
advanced non–small-cell lung cancer (NSCLC). We therefore did a meta-analysis of trials …

Expression of the transcription factor FOXP3 characterizes regulatory T cells (Tregs) that
engage in the maintenance of immunological self-tolerance and immune homeostasis. Intra-…

Purpose: The purpose of this study is to evaluate the usefulness of serum DNA methylation
of five tumor suppressor genes for early detection of lung cancer. Experimental Design: …

In this study, we evaluated the clinical usefulness of ProGRP and NSE for diagnosis and
prognosis of small-cell lung cancer (SCLC). Serum levels of ProGRP and NSE were determined …

… Conception and design: Yoshihiko Segawa, Katsuyuki Kiura, Nagio Takigawa, Haruhito
Kamei, Shingo Harita, Shunkichi Hiraki, Yoichi Watanabe, Takuo Shibayama, Toshiro Yonei …

Background: Gefitinib (‘Iressa’, ZD1839), an orally active epidermal growth factor receptor (EGFR)
tyrosine kinase inhibitor (EGFR-TKI), has shown antitumor activity in refractory …

Purpose The role of adjuvant chemotherapy in patients with resected non–small-cell lung
cancer (NSCLC) remains to be defined. This study was aimed at re-evaluating the …