Global Initiative for Asthma Strategy 2021: executive summary and rationale for key changes
…, JM FitzGerald, LJ Fleming, H Inoue… - American journal of …, 2022 - atsjournals.org
The Global Initiative for Asthma (GINA) Strategy Report provides clinicians with an annually
updated evidence-based strategy for asthma management and prevention, which can be …
updated evidence-based strategy for asthma management and prevention, which can be …
A summary of the new GINA strategy: a roadmap to asthma control
…, T Haahtela, SS Hurd, H Inoue… - European …, 2015 - Eur Respiratory Soc
Over the past 20 years, the Global Initiative for Asthma (GINA) has regularly published and
annually updated a global strategy for asthma management and prevention that has formed …
annually updated a global strategy for asthma management and prevention that has formed …
SOCS-3 regulates onset and maintenance of TH2-mediated allergic responses
Y Seki, H Inoue, N Nagata, K Hayashi, S Fukuyama… - Nature medicine, 2003 - nature.com
Members of the suppressor of cytokine signaling (SOCS) family are involved in the pathogenesis
of many inflammatory diseases. SOCS-3 is predominantly expressed in T-helper type 2 …
of many inflammatory diseases. SOCS-3 is predominantly expressed in T-helper type 2 …
Revisiting T ype 2‐high and T ype 2‐low airway inflammation in asthma: current knowledge and therapeutic implications
Asthma is a complex respiratory disorder characterized by marked heterogeneity in individual
patient disease triggers and response to therapy. Several asthma phenotypes have now …
patient disease triggers and response to therapy. Several asthma phenotypes have now …
[HTML][HTML] Key recommendations for primary care from the 2022 Global Initiative for Asthma (GINA) update
…, JM Drazen, L Duijts, L Fleming, H Inoue… - NPJ primary care …, 2023 - nature.com
The Global Initiative for Asthma (GINA) was established in 1993 by the World Health
Organization and the US National Heart Lung and Blood Institute to improve asthma awareness, …
Organization and the US National Heart Lung and Blood Institute to improve asthma awareness, …
GINA 2019: a fundamental change in asthma management: treatment of asthma with short-acting bronchodilators alone is no longer recommended for adults and …
…, R Buhl, AA Cruz, L Fleming, H Inoue… - European …, 2019 - Eur Respiratory Soc
GINA no longer recommends treating adults/adolescents with asthma with short-acting
bronchodilators alone. Instead, they should receive symptom-driven (in mild asthma) or a daily …
bronchodilators alone. Instead, they should receive symptom-driven (in mild asthma) or a daily …
[PDF][PDF] Regulation of αβ/γδ T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling
…, M Tsuji, N Yamamoto, H Han, J Tsukada, H Inoue… - Immunity, 2004 - cell.com
RBP-J is a key mediator of Notch signaling that regulates a large spectrum of cell fate
determinations. To elucidate the functions of Notch signaling in T cell development, we inactivated …
determinations. To elucidate the functions of Notch signaling in T cell development, we inactivated …
[PDF][PDF] Dectin-2 is a direct receptor for mannose-capped lipoarabinomannan of mycobacteria
…, Y Miyake, E Ishikawa, M Suzukawa, H Inoue… - Immunity, 2014 - cell.com
Mycobacteria possess various immunomodulatory molecules on the cell wall. Mannose-capped
lipoarabinomannan (Man-LAM), a major lipoglycan of Mycobacterium tuberculosis, has …
lipoarabinomannan (Man-LAM), a major lipoglycan of Mycobacterium tuberculosis, has …
Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor–β1
Suppressor of cytokine signaling (SOCS)3 is a major negative feedback regulator of signal
transducer and activator of transcription (STAT)3-activating cytokines. Transgenic mouse …
transducer and activator of transcription (STAT)3-activating cytokines. Transgenic mouse …
The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells
…, A Hijikata, Y Matsunaga, K Matsumoto, H Inoue… - Nature …, 2011 - nature.com
The immunoregulatory cytokine interleukin 10 (IL-10) is expressed mainly by T helper type
2 (T H 2) cells but also by T H 1 cells during chronic infection. Here we observed plasticity in …
2 (T H 2) cells but also by T H 1 cells during chronic infection. Here we observed plasticity in …