Aurora-A—a guardian of poles

T Marumoto, D Zhang, H Saya - Nature Reviews Cancer, 2005 - nature.com
The three human homologues of Aurora kinases (A, B and C) are essential for proper execution
of various mitotic events and are important for maintaining genomic integrity. Aurora-A is …

Mechanism and biological significance of CD44 cleavage

O Nagano, H Saya - Cancer science, 2004 - Wiley Online Library
There are multiple steps in the metastasis of cancer cells. Tumor cells must first detach from
the tumor mass and invade the surrounding extracellular matrix (ECM). In this step, cell …

[HTML][HTML] Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells

…, T Marumoto, D Zhang, M Nitta, K Hatakeyama, H Saya - Cell, 2003 - cell.com
Aurora family kinases contribute to regulation of mitosis. Using RNA interference in
synchronized HeLa cells, we now show that Aurora-A is required for mitotic entry. We found that …

[PDF][PDF] CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc− and thereby promotes tumor growth

…, Y Baba, M Ohmura, M Suematsu, H Baba, H Saya - Cancer cell, 2011 - cell.com
CD44 is an adhesion molecule expressed in cancer stem-like cells. Here, we show that a
CD44 variant (CD44v) interacts with xCT, a glutamate-cystine transporter, and controls the …

Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent

…, R Nakamura, T Akiyama, S Hadano, M Aoki, H Saya… - Nature medicine, 2018 - nature.com
Amyotrophic lateral sclerosis (ALS) is a heterogeneous motor neuron disease for which no
effective treatment is available, despite decades of research into SOD1-mutant familial ALS (…

CD44s Regulates the TGF-β–mediated mesenchymal phenotype and is associated with poor prognosis in patients with hepatocellular carcinoma

…, M Watanabe, T Beppu, M Tamada, O Nagano, H Saya… - Cancer research, 2012 - AACR
The prognosis for individuals diagnosed with hepatocellular carcinoma (HCC) remains poor
because of the high frequency of invasive tumor growth, intrahepatic spread, and …

[HTML][HTML] LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development

…, JH Kim, S Kuninaka, EN Olson, H Saya… - Nature …, 2016 - nature.com
The Hippo pathway regulates the self-renewal and differentiation of various adult stem cells,
but its role in cell fate determination and differentiation during liver development remains …

Therapeutic strategies targeting cancer stem cells

GJ Yoshida, H Saya - Cancer science, 2016 - Wiley Online Library
Cancer stem cells ( CSC s) are undifferentiated cancer cells with a high tumorigenic activity,
the ability to undergo self‐renewal, and a multilineage differentiation potential. Cancer stem …

Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme

…, T Kamiryo, M Kochi, H Nakamura, K Makino, H Saya… - Cancer research, 2003 - AACR
Glioblastoma multiforme (GBM) frequently involves amplification and alteration of the
epidermal growth factor receptor (EGFR) gene, resulting in overexpression of varied mutations, …

Mitogenic signalling and the p16INK4a–Rb pathway cooperate to enforce irreversible cellular senescence

…, K Nakayama, KI Nakayama, T Ide, H Saya… - Nature cell …, 2006 - nature.com
The p16 INK4a cyclin-dependent kinase inhibitor has a key role in establishing stable G1
cell-cycle arrest through activating the retinoblastoma (Rb) tumour suppressor protein pRb 1 , …