The myofibroblast at a glance

…, R Schuster, A Goodwin, H Karvonen… - Journal of Cell …, 2020 - journals.biologists.com
In 1971, Gabbiani and co-workers discovered and characterized the “modification of fibroblasts
into cells which are capable of an active spasm” (contraction) in rat wound granulation …

Effect of [alpha]-linolenic acid [ndash] rich Camelina sativa oil on serum fatty acid composition and serum lipids in hypercholesterolemic subjects

HM Karvonen, A Aro, NS Tapola… - Metabolism …, 2002 - metabolismjournal.com
Camelina sativa[ndash ]derived oil (camelina oil) is a good source of [alpha ]-linolenic acid.
The proportion of [alpha ]-linolenic acid in serum fatty acids is associated with the risk of …

[HTML][HTML] Pirfenidone and nintedanib modulate properties of fibroblasts and myofibroblasts in idiopathic pulmonary fibrosis

ST Lehtonen, A Veijola, H Karvonen… - Respiratory …, 2016 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is an incurable lung disease with a poor
prognosis. Fibroblasts and myofibroblasts are the key cells in the fibrotic process. Recently two …

Cadherin-11–mediated adhesion of macrophages to myofibroblasts establishes a profibrotic niche of active TGF-β

M Lodyga, E Cambridge, HM Karvonen, P Pakshir… - Science …, 2019 - science.org
Macrophages contribute to the activation of fibroblastic cells into myofibroblasts, which
secrete collagen and contract the collagen matrix to acutely repair injured tissue. Persistent …

[HTML][HTML] Myofibroblast expression in airways and alveoli is affected by smoking and COPD

HM Karvonen, ST Lehtonen, T Harju, RT Sormunen… - Respiratory …, 2013 - Springer
Background Chronic obstructive pulmonary disease (COPD) is characterized by structural
changes in alveoli and airways. Our aim was to analyse the numbers of alpha-smooth muscle …

[HTML][HTML] Lung cancer–associated myofibroblasts reveal distinctive ultrastructure and function

HM Karvonen, ST Lehtonen, RT Sormunen… - Journal of Thoracic …, 2014 - Elsevier
Background: Cancer-associated stromal cells interact with carcinoma cells and thus participate
in tumor growth. Our aim was to characterize the ultrastructure and contractile properties …

[HTML][HTML] Myofibroblasts in interstitial lung diseases show diverse electron microscopic and invasive features

HM Karvonen, ST Lehtonen, RT Sormunen… - Laboratory …, 2012 - Elsevier
The characteristic features of myofibroblasts in various lung disorders are poorly understood.
We have evaluated the ultrastructure and invasive capacities of myofibroblasts cultured …

The effect of meat products enriched with plant sterols and minerals on serum lipids and blood pressure

NS Tapola, ML Lyyra, HM Karvonen… - … journal of food …, 2004 - Taylor & Francis
The purpose of the study was to investigate the effect of non-esterified plant sterol-enriched
and mineral-enriched low-fat and low-salted meat products compared with control meat …

Mucin-1 correlates with survival, smoking status, and growth patterns in lung adenocarcinoma

E Lappi-Blanco, JM Mäkinen, S Lehtonen, H Karvonen… - Tumor Biology, 2016 - Springer
Mucin-1 (MUC1) affects cancer progression in lung adenocarcinoma, and its aberrant expression
pattern has been correlated with poor tumor differentiation and impaired prognosis. In …

Validation of a semi-quantitative FFQ using food records as a reference in older women in the Kuopio Fracture Prevention Study (OSTPRE-FPS)

AT Erkkilä, R Järvinen, H Karvonen, L Keronen… - Public Health …, 2012 - cambridge.org
ObjectiveTo validate an eighty-nine-item semi-quantitative FFQ for measurement of nutrient
intakes in elderly women.DesignFFQ and 3 d food records were filled in by women …