User profiles for Heather Lynn
Heather LynnProject Scientist Verified email at hayatx.com Cited by 513 |
Validation of a 52-gene risk profile for outcome prediction in patients with idiopathic pulmonary fibrosis: an international, multicentre, cohort study
Background The clinical course of idiopathic pulmonary fibrosis (IPF) is unpredictable.
Clinical prediction tools are not accurate enough to predict disease outcomes. Methods We …
Clinical prediction tools are not accurate enough to predict disease outcomes. Methods We …
BAL cell gene expression is indicative of outcome and airway basal cell involvement in idiopathic pulmonary fibrosis
Rationale: Idiopathic pulmonary fibrosis (IPF) is a fatal disease with a variable and unpredictable
course. Objectives: To determine whether BAL cell gene expression is predictive of …
course. Objectives: To determine whether BAL cell gene expression is predictive of …
[HTML][HTML] Development of a biomarker mortality risk model in acute respiratory distress syndrome
C Bime, N Casanova, RC Oita, J Ndukum, H Lynn… - Critical Care, 2019 - Springer
Background There is a compelling unmet medical need for biomarker-based models to risk-stratify
patients with acute respiratory distress syndrome. Effective stratification would …
patients with acute respiratory distress syndrome. Effective stratification would …
Multiple fibroblast subtypes contribute to matrix deposition in pulmonary fibrosis
Progressive pulmonary fibrosis results from a dysfunctional tissue repair response and is
characterized by fibroblast proliferation, activation, and invasion and extracellular matrix …
characterized by fibroblast proliferation, activation, and invasion and extracellular matrix …
Transcriptomics of bronchoalveolar lavage cells identifies new molecular endotypes of sarcoidosis
…, A Mihaljinec, TN Woolard, H Lynn… - European …, 2021 - Eur Respiratory Soc
Background Sarcoidosis is a multisystem granulomatous disease of unknown origin with a
variable and often unpredictable course and pattern of organ involvement. In this study we …
variable and often unpredictable course and pattern of organ involvement. In this study we …
Direct extracellular NAMPT involvement in pulmonary hypertension and vascular remodeling. Transcriptional regulation by SOX and HIF-2α
We previously demonstrated involvement of NAMPT (nicotinamide phosphoribosyltransferase)
in pulmonary arterial hypertension (PAH) and now examine NAMPT regulation and …
in pulmonary arterial hypertension (PAH) and now examine NAMPT regulation and …
Genomic and genetic approaches to deciphering acute respiratory distress syndrome risk and mortality
H Lynn, X Sun, N Casanova… - Antioxidants & redox …, 2019 - liebertpub.com
Significance: Acute respiratory distress syndrome (ARDS) is a severe, highly heterogeneous
critical illness with staggering mortality that is influenced by environmental factors, such as …
critical illness with staggering mortality that is influenced by environmental factors, such as …
[HTML][HTML] Abnormal respiratory progenitors in fibrotic lung injury
Recent advances in single-cell RNA sequencing (scRNA-seq) and epithelium lineage labeling
have yielded identification of multiple abnormal epithelial progenitor populations during …
have yielded identification of multiple abnormal epithelial progenitor populations during …
Learning by doing: The characteristics, effectiveness, and persistence of teachers who were teaching assistants first
…, DC Kershaw, KC Bastian, HH Lynn - Teachers College …, 2015 - journals.sagepub.com
Background/Context In response to a shortage of highly qualified teachers, states and school
districts have enacted a number of policy innovations over the last two decades. While …
districts have enacted a number of policy innovations over the last two decades. While …
A cortactin CTTN coding SNP contributes to lung vascular permeability and inflammatory disease severity in African descent subjects
The cortactin gene (CTTN), encoding an actin-binding protein critically involved in
cytoskeletal dynamics and endothelial cell (EC) barrier integrity, contains single nucleotide …
cytoskeletal dynamics and endothelial cell (EC) barrier integrity, contains single nucleotide …