User profiles for Heather Lynn

Heather Lynn

Project Scientist
Verified email at hayatx.com
Cited by 513

Validation of a 52-gene risk profile for outcome prediction in patients with idiopathic pulmonary fibrosis: an international, multicentre, cohort study

…, Q Li, JA Villalba, A Tzouvelekis, H Lynn… - The Lancet …, 2017 - thelancet.com
Background The clinical course of idiopathic pulmonary fibrosis (IPF) is unpredictable.
Clinical prediction tools are not accurate enough to predict disease outcomes. Methods We …

BAL cell gene expression is indicative of outcome and airway basal cell involvement in idiopathic pulmonary fibrosis

…, M Hess, S Rittinghausen, L Vuga, H Lynn… - American journal of …, 2019 - atsjournals.org
Rationale: Idiopathic pulmonary fibrosis (IPF) is a fatal disease with a variable and unpredictable
course. Objectives: To determine whether BAL cell gene expression is predictive of …

[HTML][HTML] Development of a biomarker mortality risk model in acute respiratory distress syndrome

C Bime, N Casanova, RC Oita, J Ndukum, H Lynn… - Critical Care, 2019 - Springer
Background There is a compelling unmet medical need for biomarker-based models to risk-stratify
patients with acute respiratory distress syndrome. Effective stratification would …

Multiple fibroblast subtypes contribute to matrix deposition in pulmonary fibrosis

X Liu, K Dai, X Zhang, G Huang, H Lynn… - American Journal of …, 2023 - atsjournals.org
Progressive pulmonary fibrosis results from a dysfunctional tissue repair response and is
characterized by fibroblast proliferation, activation, and invasion and extracellular matrix …

Transcriptomics of bronchoalveolar lavage cells identifies new molecular endotypes of sarcoidosis

…, A Mihaljinec, TN Woolard, H Lynn… - European …, 2021 - Eur Respiratory Soc
Background Sarcoidosis is a multisystem granulomatous disease of unknown origin with a
variable and often unpredictable course and pattern of organ involvement. In this study we …

Direct extracellular NAMPT involvement in pulmonary hypertension and vascular remodeling. Transcriptional regulation by SOX and HIF-2α

…, N Casanova, H Tang, A Gupta, H Lynn… - American journal of …, 2020 - atsjournals.org
We previously demonstrated involvement of NAMPT (nicotinamide phosphoribosyltransferase)
in pulmonary arterial hypertension (PAH) and now examine NAMPT regulation and …

Genomic and genetic approaches to deciphering acute respiratory distress syndrome risk and mortality

H Lynn, X Sun, N Casanova… - Antioxidants & redox …, 2019 - liebertpub.com
Significance: Acute respiratory distress syndrome (ARDS) is a severe, highly heterogeneous
critical illness with staggering mortality that is influenced by environmental factors, such as …

[HTML][HTML] Abnormal respiratory progenitors in fibrotic lung injury

T Xie, H Lynn, WC Parks, B Stripp, P Chen… - Stem Cell Research & …, 2022 - Springer
Recent advances in single-cell RNA sequencing (scRNA-seq) and epithelium lineage labeling
have yielded identification of multiple abnormal epithelial progenitor populations during …

Learning by doing: The characteristics, effectiveness, and persistence of teachers who were teaching assistants first

…, DC Kershaw, KC Bastian, HH Lynn - Teachers College …, 2015 - journals.sagepub.com
Background/Context In response to a shortage of highly qualified teachers, states and school
districts have enacted a number of policy innovations over the last two decades. While …

A cortactin CTTN coding SNP contributes to lung vascular permeability and inflammatory disease severity in African descent subjects

…, S Sammani, ME Brown, J Mascarhenas, H Lynn… - Translational …, 2022 - Elsevier
The cortactin gene (CTTN), encoding an actin-binding protein critically involved in
cytoskeletal dynamics and endothelial cell (EC) barrier integrity, contains single nucleotide …