User profiles for Harvey O Coxson

Harvey Coxson

Principal Scientist - Boehringer Ingelheim
Verified email at boehringer-ingelheim.com
Cited by 34590

[HTML][HTML] The nature of small-airway obstruction in chronic obstructive pulmonary disease

…, RM Rogers, FC Sciurba, HO Coxson… - … England Journal of …, 2004 - Mass Medical Soc
Background Chronic obstructive pulmonary disease (COPD) is a major public health
problem associated with long-term exposure to toxic gases and particles. We examined the …

[HTML][HTML] Characterisation of COPD heterogeneity in the ECLIPSE cohort

A Agusti, PMA Calverley, B Celli, HO Coxson… - Respiratory …, 2010 - Springer
Background Chronic obstructive pulmonary disease (COPD) is a complex condition with
pulmonary and extra-pulmonary manifestations. This study describes the heterogeneity of …

[HTML][HTML] Small-airway obstruction and emphysema in chronic obstructive pulmonary disease

…, WB Gefter, L Litzky, HO Coxson… - … England Journal of …, 2011 - Mass Medical Soc
Background The major sites of obstruction in chronic obstructive pulmonary disease (COPD)
are small airways (<2 mm in diameter). We wanted to determine whether there was a …

[HTML][HTML] Changes in forced expiratory volume in 1 second over time in COPD

…, PMA Calverley, B Celli, HO Coxson… - … England Journal of …, 2011 - Mass Medical Soc
Background A key feature of chronic obstructive pulmonary disease (COPD) is an accelerated
rate of decline in forced expiratory volume in 1 second (FEV 1 ), but data on the variability …

[HTML][HTML] Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype

…, C Crim, JC Yates, EK Silverman, HO Coxson… - PloS one, 2012 - journals.plos.org
Background Because chronic obstructive pulmonary disease (COPD) is a heterogeneous
condition, the identification of specific clinical phenotypes is key to developing more effective …

Evaluation of COPD longitudinally to identify predictive surrogate end-points (ECLIPSE)

J Vestbo, W Anderson, HO Coxson… - European …, 2008 - Eur Respiratory Soc
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease and not well
understood. The forced expiratory volume in one second is used for the diagnosis and staging …

Amplification of inflammation in emphysema and its association with latent adenoviral infection

…, WM Elliott, B Meshi, HO Coxson… - American journal of …, 2001 - atsjournals.org
This study examines the hypothesis that the cigarette smoke-induced inflammatory process
is amplified in severe emphysema and explores the association of this response with latent …

Antielastin autoimmunity in tobacco smoking–induced emphysema

…, J Hacken-Bitar, J Huh, F Bakaeen, HO Coxson… - Nature medicine, 2007 - nature.com
Chronic obstructive pulmonary disease and emphysema are common destructive inflammatory
diseases that are leading causes of death worldwide. Here we show that emphysema is …

An official American Thoracic Society/European Respiratory Society statement: research questions in chronic obstructive pulmonary disease

…, EM Clini, CB Cooper, HO Coxson… - American journal of …, 2015 - atsjournals.org
Background: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity,
mortality, and resource use worldwide. The goal of this Official American Thoracic Society (…

[HTML][HTML] Comorbidity, systemic inflammation and outcomes in the ECLIPSE cohort

…, P Bakke, PMA Calverley, B Celli, HO Coxson… - Respiratory …, 2013 - Elsevier
Comorbidities, are common in COPD, have been associated with poor outcomes and are
thought to relate to systemic inflammation. To investigate comorbidities in relation to systemic …