… Author links open overlay panel Harm J. Bogaard MD, PhD 1 a , Kohtaro Abe MD, PhD c ,
… However, the same approach may be harmful in a patient with a nonfailing hypertrophic RV …

Severe forms of pulmonary arterial hypertension (PAH) are characterized by various degrees
of remodeling of the pulmonary arterial vessels, which increases the pulmonary vascular …

There is increasing recognition of the crucial role of the right ventricle (RV) in determining
functional status and prognosis in multiple conditions. The normal RV is anatomically and …

Background— The most important determinant of longevity in pulmonary arterial hypertension
is right ventricular (RV) function, but in contrast to experimental work elucidating the …

Pulmonary arterial hypertension (PAH) is a rare disorder with a poor prognosis. Deleterious
variation within components of the transforming growth factor-β pathway, particularly the …

Pulmonary arterial hypertension (PAH) is no longer an orphan disease. There are three
different classes of drugs for the treatment of PAH that are currently being used and an …

Rationale: Most patients with pulmonary arterial hypertension (PAH) die from right heart
failure. β-Adrenergic receptor blockade reduces mortality by about 30% in patients with left-…

Background: Right ventricular (RV) adaptation to acute and chronic pulmonary hypertensive
syndromes is a significant determinant of short- and long-term outcomes. Although …

Many chronic pulmonary diseases are associated with pulmonary hypertension (PH) and
pulmonary vascular remodeling, which is a term that continues to be used to describe a wide …

Background— Right ventricular (RV) dysfunction (RVD) is the most frequent cause of death
in patients with pulmonary arterial hypertension. Although abnormal energy substrate use …