A European Respiratory Society technical standard: exhaled biomarkers in lung disease

…, Q Jöbsis, K Van De Kant, HH Knobel… - European …, 2017 - Eur Respiratory Soc
Breath tests cover the fraction of nitric oxide in expired gas (F ENO ), volatile organic compounds
(VOCs), variables in exhaled breath condensate (EBC) and other measurements. For …

Exhaled air molecular profiling in relation to inflammatory subtype and activity in COPD

…, S Peters, T Dekker, HH Knobel… - European …, 2011 - Eur Respiratory Soc
Eosinophilic inflammation in chronic obstructive pulmonary disease (COPD) is predictive for
responses to inhaled steroids. We hypothesised that the inflammatory subtype in mild and …

Exhaled breath metabolomics as a noninvasive diagnostic tool for acute respiratory distress syndrome

LDJ Bos, H Weda, Y Wang, HH Knobel… - European …, 2014 - Eur Respiratory Soc
There is a need for biological markers of the acute respiratory distress syndrome (ARDS).
Exhaled breath contains hundreds of metabolites in the gas phase, some of which reflect (…

Exhaled breath profiles in the monitoring of loss of control and clinical recovery in asthma

…, CJ Majoor, MM Sneeboer, HH Knobel… - Clinical & …, 2017 - Wiley Online Library
Background Asthma is a chronic inflammatory airway disease, associated with episodes of
exacerbations. Therapy with inhaled corticosteroids ( ICS ) targets airway inflammation, …

Identification and prospective stability of electronic nose (eNose)–derived inflammatory phenotypes in patients with severe asthma

…, Y Wang, H Weda, HH Knobel… - Journal of Allergy and …, 2019 - Elsevier
Background Severe asthma is a heterogeneous condition, as shown by independent cluster
analyses based on demographic, clinical, and inflammatory characteristics. A next step is to …

Effect of transportation and storage using sorbent tubes of exhaled breath samples on diagnostic accuracy of electronic nose analysis

…, TME Nijsen, R Raabe, HH Knobel… - Journal of breath …, 2012 - iopscience.iop.org
Many (multi-centre) breath-analysis studies require transport and storage of samples. We
aimed to test the effect of transportation and storage using sorbent tubes of exhaled breath …

[HTML][HTML] Exhaled breath metabolomics for the diagnosis of pneumonia in intubated and mechanically-ventilated intensive care unit (ICU)-patients

PMP Van Oort, S De Bruin, H Weda, HH Knobel… - International journal of …, 2017 - mdpi.com
The diagnosis of hospital-acquired pneumonia remains challenging. We hypothesized that
analysis of volatile organic compounds (VOCs) in exhaled breath could be used to diagnose …

Exhaled breath analysis with electronic nose technology for detection of acute liver failure in rats

…, MAW Maas, LDJ Bos, PJ Sterk, HH Knobel… - Biosensors and …, 2014 - Elsevier
The aim of this study was to assess the classification accuracy of an e-Nose in detecting acute
liver failure (ALF) in rats. Exhaled breath from 14 rats was repeatedly sampled by e-Nose (…

[HTML][HTML] Volatomic analysis identifies compounds that can stratify non-alcoholic fatty liver disease

…, NZM Homer, E Bower, P Brinkman, HH Knobel… - JHEP Reports, 2020 - Elsevier
Background & aims Analysis of volatile organic compounds (VOCs) in exhaled breath, ‘volatomics’,
provides opportunities for non-invasive biomarker discovery and novel mechanistic …

Exhaled volatile organic compounds as markers for medication use in asthma

…, WM Ahmed, C Gómez, HH Knobel… - European …, 2020 - Eur Respiratory Soc
Knobel, Hans Weda, Teunis J. Vink, Tamara M. Nijsen, Craig … HH Knobel: wet lab analysis
(GC-MS). H. Weda: dry lab … Conflict of interest: HH Knobel has a patent “Inline drying of breath …