… pneumoniae-infected mice express IFN-γ transcripts ex vivo (A Gigliotti-Rothfuchs, H Wigzell,
ME Rottenberg, unpublished data). The relevance of this pathway in the context of a more …

By using the two criteria (a) high density of immunoglobulin determinants on the cell surface
and (b) presence of receptors for C'3 on the cell surface for defining bone marrow-derived …

In the spleens of young, adult mice there exist naturally occurring killer lymphocytes with
specificity for mouse Moloney leukemia cells. The lytic activity was directed against syngeneic …

Normal mice contain cytolytic cells with specificity for in vitro grown mouse Moloney leukemia
cells. Such killer cells are most frequent in the spleens; lymph node and bone marrow …

We identified antibacterial components in human T and natural killer (NK) cells by using freshly
isolated lymphocytes enriched for T and NK cells as starting material. After growing these …

The epithelia constitute a major barrier to the environment and provide the first line of defense
against invading microbes. Antimicrobial peptides are emerging as participants in the …

… Chart 2 illustrates this for another type of cytotoxic test, based on the release of 51Cr from
labeled target cells, performed as described by Wigzell (18). It will be seen that the reactivity of …

Antibacterial peptides are active defense components of innate immunity. Several studies
confirm their importance at epithelial surfaces as immediate barrier effectors in preventing …

… h supernatant medium showing arginase activity (A) and colony inhibition (G) of V79 cells. 48
h … Ig anti-Ig column was prepared and run as described by Wigzell“. The increase of NK cell …

We have prepared monoclonal hapten-specific mouse IgG2b antibodies depleted of
asparagine-linked carbohydrate chains by treating the hybridoma cells with tunicamycin. The …