Association of endothelin-1 with normal tension glaucoma: clinical and fundamental studies

T Sugiyama, S Moriya, H Oku, I Azuma - Survey of ophthalmology, 1995 - Elsevier
Impaired ocular blood flow is suspected to be one of the causes of normal tension glaucoma
(NTG). We investigated whether endothelin (ET), a potent and continuous vasoacting …

[HTML][HTML] Coordinated actions of glyoxalase and antioxidant defense systems in conferring abiotic stress tolerance in plants

…, JA Mahmud, A Rahman, M Inafuku, H Oku… - International journal of …, 2017 - mdpi.com
… Normally, heavy metal (HM) stress affects the H 2 O oxidizing system of PS II because HMs
are able to replace Ca 2+ and Mn 2+ ions in the PS II reaction center; thus, hindering the …

Nitric oxide-induced salt stress tolerance in plants: ROS metabolism, signaling, and molecular interactions

M Hasanuzzaman, H Oku, K Nahar… - Plant Biotechnology …, 2018 - Springer
… oxygen (ROS) or by the addition of H 2 O 2 . Addition of … H 2 S and NO modulated the
expression of K + /Na + transporters in NaCl-affected roots of barley. H 2 S and NO amplified PM H

Antifibrotic action of pirfenidone and prednisolone: different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis

H Oku, T Shimizu, T Kawabata, M Nagira, I Hikita… - European journal of …, 2008 - Elsevier
Pirfenidone, a broad-spectrum antifibrotic agent, is known to have efficacy in certain fibrotic
disease models, and is under clinical trials in patients with idiopathic pulmonary fibrosis. We …

A male and hermaphrodite specific RAPD marker for papaya (Carica papaya L.)

…, K Tarora, Y Ban, T Kayano, H Tanaka, H Oku… - Theoretical and applied …, 2002 - Springer
… to be localized on the chromosome segment including Sex1-H and Sex1-M alleles. We
hypothesize that chromosomes containing Sex1-H, Sex1-M and Sex1-f alleles are differentiated …

A novel anti-fibrotic agent pirfenidone suppresses tumor necrosis factor-α at the translational level

H Nakazato, H Oku, S Yamane, Y Tsuruta… - European journal of …, 2002 - Elsevier
… The level of TNF-α mRNA at 2 h after the pirfenidone addition at 4 h after the lipopolysaccharide
challenge was same as that at 6 h after the lipopolysaccharide challenge (data not …

Hydroalcoholic extract based-ointment from Punica granatum L. peels with enhanced in vivo healing potential on dermal wounds

…, Z Bellasfar, M Abedrabba, H Iwaski, H Oku… - Phytomedicine, 2011 - Elsevier
The present study reports for the first time, the in vivo wound healing potential of Punica
granatum L. peels. A 5% (w/w) methanolic extract based-ointment was formulated and evaluated …

Pirfenidone inhibits the expression of HSP47 in TGF-β1-stimulated human lung fibroblasts

…, H Soda, H Oku, Y Urata, T Kondo, H Kubota… - Life sciences, 2008 - Elsevier
… Treatment with TGF-β1 for 48 h significantly increased the average rate of our grading score
for both HSP47 (Fig. 7) and collagen type I (Fig. 8) expression (n = 5), whereas pirfenidone …

Pirfenidone attenuates expression of HSP47 in murine bleomycin-induced pulmonary fibrosis

…, T Hayashi, H Ishii, K Abe, T Fujii, H Oku… - European …, 2004 - Eur Respiratory Soc
Heat shock protein (HSP) 47, a collagen-specific molecular chaperone, is involved in the
processing and/or secretion of procollagen. The present study was undertaken to investigate …

Effect of branched-chain fatty acids on fatty acid biosynthesis of human breast cancer cells

S Wongtangtintharn, H Oku, H Iwasaki… - Journal of nutritional …, 2004 - jstage.jst.go.jp
… 80 for 24 h. To this cell culture … 11) Beere H. 2001. Apoptosis hots up from the cold. …
22) Ide T, Kobayashi H, Ashakumary L, Rouyer IA, Taka hashi Y, Aoyama T, Hashimoto H …