Disruption of the cyclin-dependent kinase–inhibitory domain of p27 enhances growth of mice.
Growth is attributed to an increase in cell number, due to increased cell proliferation, most …

… Female mice (120–122 days old) from all groups were fasted for 6 to 7 h. Mice were injected
with 0.75 IU/kg BW regular insulin (Humulin R, Eli Lilly, Indianapolis, IN) ip, and then blood …

… Notch-active cells were detected 12 h post injury (hpi), with a peak at 36 hpi. The fact that
most of the Notch reporter-positive cells were p63- (basal cell marker) and Krt8 + (luminal cell …

Cyclin D1 is overexpressed in the majority of human breast cancers. We previously found
that mice lacking cyclin D1 are resistant to mammary carcinomas triggered by the ErbB-2 …

… of CDKs bound to p27 in cells 18 h after serum stimulation by … from cell lysates prepared
18 h after serum stimulation. The … embryos were serum starved for 72 h (time zero) and then …

… When Cdk4 −/− MEFs are released from quiescence, Cdk2 activity is decreased concomitantly
with a 4-h delay in S-phase entry 7 . Ablation of p27 in Cdk4 −/− MEFs rescues the delay …

The Forkhead Box (Fox) proteins are an extensive family of transcription factors that shares
homology in the winged helix DNA-binding domain and whose members play essential roles …

A method is described for identifying different genotypes of hepatitis C virus (HCV) by restriction
endonuclease cleavage of sequences amplified by PCR from the 5′ non-coding region…

BACKGROUND Tumor‐related leukocytosis is a paraneoplastic syndrome that is encountered
occasionally in the clinical course of patients with lung carcinoma. Recently, autonomous …

p21Cip1/WAF1 was the first cyclin-dependent kinase (CDK) inhibitor to be identified, as a
mediator of p53 in DNA damage-induced growth arrest, cell senescence, and direct CDK …