Polyomavirus-associated nephropathy in renal transplantation: interdisciplinary analyses and recommendations

HH Hirsch, DC Brennan, CB Drachenberg… - …, 2005 - journals.lww.com
Polyomavirus-associated nephropathy (PVAN) is an emerging cause of kidney transplant
failure affecting 1–10% of patients. As uncertainty exists regarding risk factors, diagnosis, and …

Polyomavirus Bk

HH Hirsch, J Steiger - The Lancet infectious diseases, 2003 - thelancet.com
Polyomavirus hominis 1, better known as BK virus (BKV), infects up to 90% of the general
population. However, significant clinical manifestations are rare and limited to individuals with …

Natalizumab treatment for multiple sclerosis: updated recommendations for patient selection and monitoring

…, HL Weiner, M Clanet, R Gold, HH Hirsch… - The Lancet …, 2011 - thelancet.com
Natalizumab, a highly specific α4-integrin antagonist, is approved for treatment of patients
with active relapsing-remitting multiple sclerosis (RRMS). It is generally recommended for …

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

…, A Ameur, S Enroth, MC Bieda, CM Koch, HA Hirsch… - nature, 2007 - nature.com
We report the generation and analysis of functional data from multiple, diverse experiments
performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE …

The ENCODE (ENCyclopedia of DNA elements) project

…, D Kampa, EA Sekinger, J Cheng, H Hirsch… - Science, 2004 - scholarworks.bwise.kr
The ENCyclopedia Of DNA Elements (ENCODE) Project aims to identify all functional elements
in the human genome sequence. The pilot phase of the Project is focused on a specified …

The Aurora experimental framework for the performance evaluation of speech recognition systems under noisy conditions

HG Hirsch, D Pearce - … speech recognition: challenges for the new …, 2000 - isca-speech.org
The TIDigits database is taken as basis. This part is considered that contains the recordings
of male and female US-American adults speaking isolated digits and sequences of up to 7 …

[HTML][HTML] Prospective study of polyomavirus type BK replication and nephropathy in renal-transplant recipients

HH Hirsch, W Knowles, M Dickenmann… - … England Journal of …, 2002 - Mass Medical Soc
Background Nephropathy associated with the polyomavirus type BK (BKV) nephropathy has
emerged as a cause of allograft failure linked to immunosuppressive regimens containing …

[HTML][HTML] An epigenetic switch involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation

D Iliopoulos, HA Hirsch, K Struhl - Cell, 2009 - cell.com
Inflammation is linked clinically and epidemiologically to cancer, and NF-κB appears to play
a causative role, but the mechanisms are poorly understood. We show that transient …

Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission

HA Hirsch, D Iliopoulos, PN Tsichlis, K Struhl - Cancer research, 2009 - AACR
… Morphologic changes, phenotypic transformation, and foci formation occurred 24 to 36 h
after … Images were captured by phase-contrast microscopy at 0 and 12 h after wounding. …

Prevalence of polyomavirus BK and JC infection and replication in 400 healthy blood donors

…, C Stebler, R Gosert, HH Hirsch - The Journal of …, 2009 - academic.oup.com
BackgroundThe replication of BK virus (BKV) and JC virus (JCV) is linked to polyomavirus-associated
nephropathy, hemorrhagic cystitis, and multifocal leukoencephalopathy in …