Purpose: Presence of pelvic lymph node metastases is the main prognostic factor in early-stage
cervical cancer patients, primarily treated with surgery. Aim of this study was to identify …

Current cervical cancer screening is based on morphological assessment of Pap smears
and associated with significant false negative and false positive results. Previously, we have …

The mucin-like glycoprotein episialin (MUC1) is highly overproduced by a number of human
carcinomas. We have shown previously in a variety of mammalian cell lines that …

Purpose: Recently, we reported 13 possible cervical cancer–specific methylated biomarkers
identified by pharmacologic unmasking microarray in combination with large-genome …

Objectives: To determine methylation status of nine genes, previously described to be
frequently methylated in cervical cancer, in squamous intraepithelial lesions (SIL). Methods: …

OBJECTIVE: To explore the feasibility of DNA methylation analysis for the detection of cervical
neoplasia in self-obtained cervico-vaginal lavages. METHODS: Lavages collected by a …

… Pap smear were diagnosed by biopsy or LLETZ (large loop excision of the transformation
zone) and all tissue samples were scored by an experienced gynecologic pathologist (HH). …

Peroxynitrite has been shown to be crucially involved in airway hyperresponsiveness (AHR)
after the late asthmatic reaction (LAR). Peroxynitrite production may result from …

Background To discover cancer specific DNA methylation markers, large-scale screening
methods are widely used. The pharmacological unmasking expression microarray approach is …

… HH Kampinga and the department of Cell Biology for their valuable help and information on
HSPA6 experiments. Also, we thank the Parelsnoer Institute (http://www.parelsnoer.org ) that …