… Bogaard has received speaker fees from and served on advisory boards for Pfizer and
United Therapeutics. Dr. Condliffe has received speaker and/or conference travel fees from and/…

… ATII activation leads to ROS formation via upregulation of NAD(P)H oxidases; other
sources of ROS production in heart failure are xanthine oxidase, cytochrome P450, and …

Severe forms of pulmonary arterial hypertension (PAH) are characterized by various degrees
of remodeling of the pulmonary arterial vessels, which increases the pulmonary vascular …

Objectives : The purpose of this study was to examine the relationship between changes in
pulmonary vascular resistance (PVR) and right ventricular ejection fraction (RVEF) and …

Background— The most important determinant of longevity in pulmonary arterial hypertension
is right ventricular (RV) function, but in contrast to experimental work elucidating the …

… Dr Bogaard is supported by the Netherlands Cardiovascular Research Initiative: the Dutch
… Dr Bogaard received speaker fees or honoraria for consultations from Actelion, Bayer, Pfizer…

Patients diagnosed with coronavirus disease 2019 (COVID-19) become critically ill primarily
around the time of activation of the adaptive immune response. Here, we provide evidence …

There is increasing recognition of the crucial role of the right ventricle (RV) in determining
functional status and prognosis in multiple conditions. The normal RV is anatomically and …

Pulmonary arterial hypertension (PAH) is a rare disorder with a poor prognosis. Deleterious
variation within components of the transforming growth factor-β pathway, particularly the …

Pulmonary arterial hypertension (PAH) is no longer an orphan disease. There are three
different classes of drugs for the treatment of PAH that are currently being used and an …