User profiles for H Sasaki
HIROSHI SASAKIOsaka University Verified email at fbs.osaka-u.ac.jp Cited by 14980 |
The landscape of somatic copy-number alteration across human cancers
A powerful way to discover key genes with causal roles in oncogenesis is to identify
genomic regions that undergo frequent alteration in human cancers. Here we present high-…
genomic regions that undergo frequent alteration in human cancers. Here we present high-…
EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
Receptor tyrosine kinase genes were sequenced in non–small cell lung cancer (NSCLC)
and matched normal tissue. Somatic mutations of the epidermal growth factor receptor gene …
and matched normal tissue. Somatic mutations of the epidermal growth factor receptor gene …
Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase
…, Y Masuhiro, T Kitamoto, S Uchiyama, H Sasaki… - Science, 1995 - science.org
The phosphorylation of the human estrogen receptor (ER) serine residue at position 118 is
required for full activity of the ER activation function 1 (AF-1). This Ser 118 is phosphorylated …
required for full activity of the ER activation function 1 (AF-1). This Ser 118 is phosphorylated …
[HTML][HTML] Characterizing the cancer genome in lung adenocarcinoma
Somatic alterations in cellular DNA underlie almost all human cancers 1 . The prospect of
targeted therapies 2 and the development of high-resolution, genome-wide approaches 3 , 4 , …
targeted therapies 2 and the development of high-resolution, genome-wide approaches 3 , 4 , …
Size-selective loosening of the blood-brain barrier in claudin-5–deficient mice
T Nitta, M Hata, S Gotoh, Y Seo, H Sasaki… - The Journal of cell …, 2003 - rupress.org
… H magnetic resonance images were obtained using an NMR spectrometer (7.05 T;
model AMX-300wb; Bruker) with an active shielded gradient (micro2.5) and an 1 H birdcage …
model AMX-300wb; Bruker) with an active shielded gradient (micro2.5) and an 1 H birdcage …
Complex phenotype of mice lacking occludin, a component of tight junction strands
M Saitou, M Furuse, H Sasaki… - Molecular biology of …, 2000 - Am Soc Cell Biol
Occludin is an integral membrane protein with four transmembrane domains that is exclusively
localized at tight junction (TJ) strands. Here, we describe the generation and analysis of …
localized at tight junction (TJ) strands. Here, we describe the generation and analysis of …
Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes
…, T Kono, T Nakano, MA Surani, Y Sakaki, H Sasaki - Nature, 2008 - nature.com
… We also thank members of the Sasaki laboratory for discussion and encouragement. TW is
a research fellow of the Japan Society for the Promotion of Science. This work was supported …
a research fellow of the Japan Society for the Promotion of Science. This work was supported …
Identification of the spinocerebellar ataxia type 2 gene using a direct identification of repeat expansion and cloning technique, DIRECT
…, H Takano, S Igarashi, T Sato, M Oyake, H Sasaki… - Nature …, 1996 - nature.com
Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant, neurodegenerative
disorder that affects the cerebellum and other areas of the central nervous system. We have …
disorder that affects the cerebellum and other areas of the central nervous system. We have …
Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting
…, M Okano, K Hata, T Sado, N Tsujimoto, E Li, H Sasaki - Nature, 2004 - nature.com
Imprinted genes are epigenetically marked during gametogenesis so that they are
exclusively expressed from either the paternal or the maternal allele in offspring 1 . Imprinting …
exclusively expressed from either the paternal or the maternal allele in offspring 1 . Imprinting …
High-throughput oncogene mutation profiling in human cancer
…, A Dutt, C Emery, H Greulich, K Shah, H Sasaki… - Nature …, 2007 - nature.com
Systematic efforts are underway to decipher the genetic changes associated with tumor
initiation and progression 1 , 2 . However, widespread clinical application of this information is …
initiation and progression 1 , 2 . However, widespread clinical application of this information is …