User profiles for H Sasaki

HIROSHI SASAKI

Osaka University
Verified email at fbs.osaka-u.ac.jp
Cited by 14980

The landscape of somatic copy-number alteration across human cancers

…, D Yecies, S Signoretti, E Maher, FJ Kaye, H Sasaki… - Nature, 2010 - nature.com
A powerful way to discover key genes with causal roles in oncogenesis is to identify
genomic regions that undergo frequent alteration in human cancers. Here we present high-…

EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

…, FJ Kaye, N Lindeman, TJ Boggon, K Naoki, H Sasaki… - Science, 2004 - science.org
Receptor tyrosine kinase genes were sequenced in non–small cell lung cancer (NSCLC)
and matched normal tissue. Somatic mutations of the epidermal growth factor receptor gene …

Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase

…, Y Masuhiro, T Kitamoto, S Uchiyama, H Sasaki… - Science, 1995 - science.org
The phosphorylation of the human estrogen receptor (ER) serine residue at position 118 is
required for full activity of the ER activation function 1 (AF-1). This Ser 118 is phosphorylated …

[HTML][HTML] Characterizing the cancer genome in lung adenocarcinoma

…, AH Ramos, J Robinson, JA Roth, V Rusch, H Sasaki… - Nature, 2007 - nature.com
Somatic alterations in cellular DNA underlie almost all human cancers 1 . The prospect of
targeted therapies 2 and the development of high-resolution, genome-wide approaches 3 , 4 , …

Size-selective loosening of the blood-brain barrier in claudin-5–deficient mice

T Nitta, M Hata, S Gotoh, Y Seo, H Sasaki… - The Journal of cell …, 2003 - rupress.org
H magnetic resonance images were obtained using an NMR spectrometer (7.05 T;
model AMX-300wb; Bruker) with an active shielded gradient (micro2.5) and an 1 H birdcage …

Complex phenotype of mice lacking occludin, a component of tight junction strands

M Saitou, M Furuse, H Sasaki… - Molecular biology of …, 2000 - Am Soc Cell Biol
Occludin is an integral membrane protein with four transmembrane domains that is exclusively
localized at tight junction (TJ) strands. Here, we describe the generation and analysis of …

Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes

…, T Kono, T Nakano, MA Surani, Y Sakaki, H Sasaki - Nature, 2008 - nature.com
… We also thank members of the Sasaki laboratory for discussion and encouragement. TW is
a research fellow of the Japan Society for the Promotion of Science. This work was supported …

Identification of the spinocerebellar ataxia type 2 gene using a direct identification of repeat expansion and cloning technique, DIRECT

…, H Takano, S Igarashi, T Sato, M Oyake, H Sasaki… - Nature …, 1996 - nature.com
Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant, neurodegenerative
disorder that affects the cerebellum and other areas of the central nervous system. We have …

Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting

…, M Okano, K Hata, T Sado, N Tsujimoto, E Li, H Sasaki - Nature, 2004 - nature.com
Imprinted genes are epigenetically marked during gametogenesis so that they are
exclusively expressed from either the paternal or the maternal allele in offspring 1 . Imprinting …

High-throughput oncogene mutation profiling in human cancer

…, A Dutt, C Emery, H Greulich, K Shah, H Sasaki… - Nature …, 2007 - nature.com
Systematic efforts are underway to decipher the genetic changes associated with tumor
initiation and progression 1 , 2 . However, widespread clinical application of this information is …