A Task Force supported by the European Respiratory Society was set up in 1997 in order to
address the major issues relevant to difficult/therapy-resistant asthma. Although the group of …

… that the coefficient for age occurs between the ages of 18 to 25 and an HAM Kerstjens …
Weill H. Blue-collar normative spirometric values for Caucasian and African-American men and …

Protein tyrosine nitration (PTN) is a post-translational modification occurring under the action
of a nitrating agent. Tyrosine is modified in the 3-position of the phenolic ring through the …

Background: The assessment of asthma control is pivotal to the evaluation of treatment
response in individuals and in clinical trials. Previously, asthma control, severity, and …

Concepts of asthma severity and control are important in the evaluation of patients and their
response to treatment but the terminology is not standardised and the terms are often used …

Background Patients with severe asthma are often inadequately controlled on existing anti‐asthma
therapy, constituting an unmet clinical need. Objective This randomized, double‐blind…

Background Some patients with asthma have frequent exacerbations and persistent airflow
obstruction despite treatment with inhaled glucocorticoids and long-acting beta-agonists (…

Antagonizing the effect of interleukin (IL)-5 is a potential new treatment strategy in allergic
disorders. We evaluated the safety, biological activity, and pharmacokinetics of SCH55700 , a …

Background Bronchoscopic lung-volume reduction with the use of one-way endobronchial
valves is a potential treatment for patients with severe emphysema. To date, the benefits have …

Background Patients with chronic obstructive pulmonary disease (COPD) with an eosinophilic
phenotype may benefit from treatment with mepolizumab, a monoclonal antibody directed …