… In addition to parameter stability and log-likelihood stability, convergence is reached only
when d T H −1 d < ε, where d is the gradient vector and H the Hessian matrix (by default ε = 10 …

It has been postulated that oxidative stress may play a key role in dementia. This is
substantiated by the recent discovery of the protective effect of wine. In wine, the flavonoids – …

Objective Whereas cognitive deficits are known to be detectable long before the typical
symptoms of Alzheimer's disease (AD) are evident, previous studies have failed to determine …

… 4 Proust-Lima C, Amieva H, Dartigues JF, Jacqmin-Gadda H: Sensitivity of four psychometric …
5 Proust-Lima C, Dartigues JF, Jacqmin-Gadda H: Misuse of the linear mixed model when …

… France Alzheimer partly funded this work by a grant awarded to Hélène Jacqmin-Gadda
in 2009. IPSEN and Novartis laboratories funded the PAQUID study, managed by Jean-…

Better knowledge of the preclinical phase of Alzheimer's disease would be an important
advance to allow earlier treatment of this ominous disease. This prodromal period was …

… These data were described in detail by Jacqmin-Gadda et al. (18). Then all the results of
the chemical analyses of drinking water (including silica) carried out by the sanitary …

The authors examined associations between exposure to aluminum or silica from drinking
water and risk of cognitive decline, dementia, and Alzheimer's disease among elderly …

A better knowledge of long-term trajectories of cognitive decline is a central feature of the study
of the process leading to Alzheimer’s dementia. Several factors may mitigate such decline…

The Mini-Mental State Examination (MMSE) measures global cognitive performance and is
often used as a screening test for dementia. This paper presents a 5-year longitudinal study …