User profiles for H Grimes

H. Leighton Grimes

Professor, Cincinnati Children's Hospital
Verified email at cchmc.org
Cited by 12965

ELANE mutations in cyclic and severe congenital neutropenia: genetics and pathophysiology

MS Horwitz, SJ Corey, HL Grimes… - Hematology/Oncology …, 2013 - hemonc.theclinics.com
Normal neutrophil counts in peripheral blood typically range between 1500 to 8500 cells/mL
after the age of 1 year, 1 although they vary among individuals from different parts of the …

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

…, J Koster, MU Schuhmann, M Ebinger, HL Grimes… - Nature, 2014 - nature.com
Medulloblastoma is a highly malignant paediatric brain tumour currently treated with a
combination of surgery, radiation and chemotherapy, posing a considerable burden of toxicity to …

[HTML][HTML] Cyclin D expression is controlled post-transcriptionally via a phosphatidylinositol 3-kinase/Akt-dependent pathway

RC Muise-Helmericks, HL Grimes, A Bellacosa… - Journal of Biological …, 1998 - ASBMB
Cyclin D expression is regulated by growth factors and is necessary for the induction of
mitogenesis. Herbimycin A, a drug that binds to Hsp90, induces the destruction of tyrosine …

Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

NN Ahmed, HL Grimes, A Bellacosa… - Proceedings of the …, 1997 - National Acad Sciences
The interleukin-2 (IL-2) receptor (IL-2R) is composed of three subunits. Of these, IL-2Rα is
required for high-affinity IL-2 binding, while IL-2Rβ and IL-2Rγ c are required for the …

[PDF][PDF] Suppression of IL7Rα transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival

…, JS Appelbaum, D Montoya-Durango, HL Grimes… - Immunity, 2004 - cell.com
Survival of naive T cells is dependent upon IL-7, which is present in vivo in limiting amounts
with the result that naive T cells must compete for IL-7-mediated survival signals. It would …

Single-cell analysis of mixed-lineage states leading to a binary cell fate choice

…, BJ Aronow, N Salomonis, H Singh, HL Grimes - Nature, 2016 - nature.com
Delineating hierarchical cellular states, including rare intermediates and the networks of
regulatory genes that orchestrate cell-type specification, are continuing challenges for …

Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2

…, B Nakamoto, T Papayannopoulou, HL Grimes… - Nature …, 2003 - nature.com
Mice lacking the transcriptional repressor oncoprotein Gfi1 are unexpectedly neutropenic 1 ,
2 . We therefore screened GFI1 as a candidate for association with neutropenia in affected …

[PDF][PDF] Granulocyte-monocyte progenitors and monocyte-dendritic cell progenitors independently produce functionally distinct monocytes

…, BP Berman, DJ Hazelett, N Salomonis, HL Grimes… - Immunity, 2017 - cell.com
Granulocyte-monocyte progenitors (GMPs) and monocyte-dendritic cell progenitors (MDPs)
produce monocytes during homeostasis and in response to increased demand during …

Gfi-1 Encodes a Nuclear Zinc Finger Protein That Binds DNA and Functions as a Transcriptional Repressor

PA Zweidler-Mckay, HL Grimes… - … and cellular biology, 1996 - Taylor & Francis
The Gfi-1 proto-oncogene encodes a zinc finger protein with six C 2 H 2 -type, C-terminal
zinc finger motifs and is activated by provirus integration in T-cell lymphoma lines selected for …

The Gfi-1 Proto-Oncoprotein Contains a Novel Transcriptional Repressor Domain, SNAG, and Inhibits G1 Arrest Induced by Interleukin-2 Withdrawal

HL Grimes, TO Chan, PA Zweidler-McKay… - … and cellular biology, 1996 - Taylor & Francis
The Gfi-1 proto-oncogene is activated by provirus insertion in T-cell lymphoma lines
selected for interleukin-2 (IL-2) independence in culture and in primary retrovirus-induced …