User profiles for H Grimes
H. Leighton GrimesProfessor, Cincinnati Children's Hospital Verified email at cchmc.org Cited by 12965 |
ELANE mutations in cyclic and severe congenital neutropenia: genetics and pathophysiology
Normal neutrophil counts in peripheral blood typically range between 1500 to 8500 cells/mL
after the age of 1 year, 1 although they vary among individuals from different parts of the …
after the age of 1 year, 1 although they vary among individuals from different parts of the …
Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma
Medulloblastoma is a highly malignant paediatric brain tumour currently treated with a
combination of surgery, radiation and chemotherapy, posing a considerable burden of toxicity to …
combination of surgery, radiation and chemotherapy, posing a considerable burden of toxicity to …
[HTML][HTML] Cyclin D expression is controlled post-transcriptionally via a phosphatidylinositol 3-kinase/Akt-dependent pathway
RC Muise-Helmericks, HL Grimes, A Bellacosa… - Journal of Biological …, 1998 - ASBMB
Cyclin D expression is regulated by growth factors and is necessary for the induction of
mitogenesis. Herbimycin A, a drug that binds to Hsp90, induces the destruction of tyrosine …
mitogenesis. Herbimycin A, a drug that binds to Hsp90, induces the destruction of tyrosine …
Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase
NN Ahmed, HL Grimes, A Bellacosa… - Proceedings of the …, 1997 - National Acad Sciences
The interleukin-2 (IL-2) receptor (IL-2R) is composed of three subunits. Of these, IL-2Rα is
required for high-affinity IL-2 binding, while IL-2Rβ and IL-2Rγ c are required for the …
required for high-affinity IL-2 binding, while IL-2Rβ and IL-2Rγ c are required for the …
[PDF][PDF] Suppression of IL7Rα transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival
Survival of naive T cells is dependent upon IL-7, which is present in vivo in limiting amounts
with the result that naive T cells must compete for IL-7-mediated survival signals. It would …
with the result that naive T cells must compete for IL-7-mediated survival signals. It would …
Single-cell analysis of mixed-lineage states leading to a binary cell fate choice
Delineating hierarchical cellular states, including rare intermediates and the networks of
regulatory genes that orchestrate cell-type specification, are continuing challenges for …
regulatory genes that orchestrate cell-type specification, are continuing challenges for …
Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2
…, B Nakamoto, T Papayannopoulou, HL Grimes… - Nature …, 2003 - nature.com
Mice lacking the transcriptional repressor oncoprotein Gfi1 are unexpectedly neutropenic 1 ,
2 . We therefore screened GFI1 as a candidate for association with neutropenia in affected …
2 . We therefore screened GFI1 as a candidate for association with neutropenia in affected …
[PDF][PDF] Granulocyte-monocyte progenitors and monocyte-dendritic cell progenitors independently produce functionally distinct monocytes
Granulocyte-monocyte progenitors (GMPs) and monocyte-dendritic cell progenitors (MDPs)
produce monocytes during homeostasis and in response to increased demand during …
produce monocytes during homeostasis and in response to increased demand during …
Gfi-1 Encodes a Nuclear Zinc Finger Protein That Binds DNA and Functions as a Transcriptional Repressor
PA Zweidler-Mckay, HL Grimes… - … and cellular biology, 1996 - Taylor & Francis
The Gfi-1 proto-oncogene encodes a zinc finger protein with six C 2 H 2 -type, C-terminal
zinc finger motifs and is activated by provirus integration in T-cell lymphoma lines selected for …
zinc finger motifs and is activated by provirus integration in T-cell lymphoma lines selected for …
The Gfi-1 Proto-Oncoprotein Contains a Novel Transcriptional Repressor Domain, SNAG, and Inhibits G1 Arrest Induced by Interleukin-2 Withdrawal
The Gfi-1 proto-oncogene is activated by provirus insertion in T-cell lymphoma lines
selected for interleukin-2 (IL-2) independence in culture and in primary retrovirus-induced …
selected for interleukin-2 (IL-2) independence in culture and in primary retrovirus-induced …