User profiles for Guy Berchem

Guy Berchem MD, PhD

Medical Oncologist CHL and Ass. Medical Director Luxembourg Institute of Health
Verified email at chl.lu
Cited by 25853

[HTML][HTML] The critical role of the tumor microenvironment in shaping natural killer cell-mediated anti-tumor immunity

…, E Viry, J Paggetti, S Medves, G Berchem… - Frontiers in …, 2013 - frontiersin.org
Considerable evidence has been gathered over the last 10 years showing that the tumor
microenvironment (TME) is not simply a passive recipient of immune cells, but an active …

[HTML][HTML] Improving cancer immunotherapy by targeting the hypoxic tumor microenvironment: new opportunities and challenges

…, A Lequeux, M Xiao, C Duhem, S Chouaib, G Berchem… - Cells, 2019 - mdpi.com
Initially believed to be a disease of deregulated cellular and genetic expression, cancer is
now also considered a disease of the tumor microenvironment. Over the past two decades, …

[HTML][HTML] Lighting up the fire in the microenvironment of cold tumors: A major challenge to improve cancer immunotherapy

A Benoit, G Vogin, C Duhem, G Berchem, B Janji - Cells, 2023 - mdpi.com
Immunotherapy includes immune checkpoint inhibitors (ICI) such as antibodies targeting
cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) or the programmed cell death protein/…

Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts

…, J Adam, P Lichter, E Solary, G Berchem… - Blood, The Journal …, 2015 - ashpublications.org
Exosomes derived from solid tumor cells are involved in immune suppression, angiogenesis,
and metastasis, but the role of leukemia-derived exosomes has been less investigated. …

Cathepsin-D affects multiple tumor progression steps in vivo: proliferation, angiogenesis and apoptosis

G Berchem, M Glondu, M Gleizes, JP Brouillet… - Oncogene, 2002 - nature.com
Cathepsin-D is an independent marker of poor prognosis in human breast cancer. We
previously showed that human wild-type cathepsin-D, as well as its mutated form devoid of …

Granzyme B degradation by autophagy decreases tumor cell susceptibility to natural killer-mediated lysis under hypoxia

J Baginska, E Viry, G Berchem, A Poli… - Proceedings of the …, 2013 - National Acad Sciences
Recent studies demonstrated that autophagy is an important regulator of innate immune
response. However, the mechanism by which autophagy regulates natural killer (NK) cell-…

Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-β and miR23a transfer

G Berchem, MZ Noman, M Bosseler, J Paggetti… - …, 2016 - Taylor & Francis
Tumor-derived microvesicles (TD-MVs) are key mediators which are shed by cancer cells
and can sensitize neighboring cells in the tumor microenvironment. TD-MVs are extracellular …

Blocking hypoxia-induced autophagy in tumors restores cytotoxic T-cell activity and promotes regression

…, S Pierson, P Przanowski, S Buart, G Berchem… - Cancer research, 2011 - AACR
The relationship between hypoxic stress, autophagy, and specific cell-mediated cytotoxicity
remains unknown. This study shows that hypoxia-induced resistance of lung tumor to …

A secreted FGF-binding protein can serve as the angiogenic switch in human cancer

…, A Aigner, AT Tuveson, GJ Berchem… - Nature medicine, 1997 - nature.com
The growth and metastatic spread of cancer is directly related to tumor angiogenesis 1 , and
the driving factors need to be understood to exploit this process therapeutically 2,3 . …

MicroRNA as biomarkers and regulators in B-cell chronic lymphocytic leukemia

…, V Palissot, LE Hood, G Berchem… - Proceedings of the …, 2011 - National Acad Sciences
Early cancer detection and disease stratification or classification are critical to successful
treatment. Accessible, reliable, and informative cancer biomarkers can be medically valuable …