All patients with asthma are at risk of having exacerbations. Hospitalizations and emergency
department (ED) visits account for a large proportion of the health-care cost burden of …

Background: Current guidelines recommend the use of a combination of inhaled β 2 agonists
and anticholinergics, particularly for patients with acute severe or life threatening asthma in …

Background Omalizumab is a humanized monoclonal anti-IgE for the treatment of severe
allergic asthma. Because omalizumab targets an immune system molecule, there has been …

OBJECTIVE: We performed a systematic review of randomized, controlled trials to determine
whether intranasal corticosteroids offered an advantage over topical antihistamines in the …

OBJECTIVE. To compare the efficacy of inhaled corticosteroids in infants and preschoolers
with recurrent wheezing or asthma. METHODS. Randomized, prospective, controlled trials …

OBJECTIVE: To compare the efficacy of β-agonists given by metered-dose inhaler with a
valved holding chamber (MDI+VHC) or nebulizer in children under 5 years of age with acute …

Background Helium and oxygen mixtures (heliox), have been used sporadically in respiratory
medicine for decades. Their use in acute respiratory emergencies such as asthma has …

Purpose: To review the literature to determine whether inhaled ipratropium bromide provides
additive benefits to adults with acute asthma who are being treated with beta-agonists in an …

Background Current reviews on the use of inhaled corticosteroids (ICS) for acute asthma
underestimated their early (minutes) clinical impact and produced conclusions of questionable …

Background Randomized controlled trials (RCTs) indicate that long-acting bronchodilator
combinations, such as β 2 -agonist (LABA)/muscarinic antagonist (LAMA), have favorable …