Inhibition of allergic inflammation in the airways using aerosolized antisense to Syk kinase

GR Stenton, M Ulanova, RE Déry, S Merani… - The Journal of …, 2002 - journals.aai.org
Activation of the protein tyrosine kinase Syk is an early event that follows cross-linking of
FcγR and FcεR, leading to the release of biologically active molecules in inflammation. We …

Role of intestinal mast cells in modulating gastrointestinal pathophysiology

GR Stenton, H Vliagoftis, AD Befus - Annals of Allergy, Asthma & …, 1998 - Elsevier
OBJECTIVE: This article reviews the current understanding of the pathophysiologic role of
intestinal mast cells. DATA SOURCE: Up to date English language publications on mast cell …

Characterization of AQX‐1125, a small‐molecule SHIP1 activator: part 1. Effects on inflammatory cell activation and chemotaxis in vitro and pharmacokinetic …

GR Stenton, LF Mackenzie, P Tam… - British journal of …, 2013 - Wiley Online Library
Background The SH2 ‐containing inositol‐5′‐phosphatase 1 ( SHIP1 ) metabolizes PI (3,4,5)
P3 to PI (3,4) P2 . SHIP1 ‐deficient mice exhibit progressive inflammation. …

Characterization of AQX‐1125, a small‐molecule SHIP1 activator: Part 2. Efficacy studies in allergic and pulmonary inflammation models in vivo

GR Stenton, LF Mackenzie, P Tam… - British journal of …, 2013 - Wiley Online Library
Background The efficacy of AQX ‐1125, a small‐molecule SH2‐containing inositol‐5′‐phosphatase
1 ( SHIP1 ) activator and clinical development candidate, is investigated in rodent …

Aerosolized Syk antisense suppresses Syk expression, mediator release from macrophages, and pulmonary inflammation

GR Stenton, MK Kim, O Nohara, CF Chen… - The Journal of …, 2000 - journals.aai.org
Syk protein tyrosine kinase (PTK) is involved in signaling in leukocytes. In macrophages, Fcγ-receptor
cross-linking induces Syk PTK phosphorylation and activation, resulting in Syk-…

Proteinase-activated receptor (PAR)-1 and-2 agonists induce mediator release from mast cells by pathways distinct from PAR-1 and PAR-2

GR Stenton, O Nohara, RE Déry, H Vliagoftis… - … of Pharmacology and …, 2002 - ASPET
Because thrombin-induced inflammation is partially mast cell-dependent and involves
proteinase-activated receptors (PARs), we hypothesized that mast cells express PAR and can be …

Synthesis of SHIP1‐Activating Analogs of the Sponge Meroterpenoid Pelorol

…, X Wang, J Wu, C Harwig, GR Stenton… - European Journal of …, 2012 - Wiley Online Library
Two biomimetic approaches have been used to synthesize analogs of the SHIP1‐activating
sponge meroterpenoid pelorol (1). One approach started from the chiral pool plant natural …

Frontline: Inhibition of allergen‐induced pulmonary inflammation by the tripeptide feG: a mimetic of a neuro‐endocrine pathway

…, M Ulanova, L Puttagunta, GR Stenton… - European journal of …, 2004 - Wiley Online Library
Interactions between the neuro‐endocrine system and immune system help maintain health.
One interaction involves the superior cervical ganglia (SCG), which regulate the …

Involvement of Syk protein tyrosine kinase in LPS-induced responses in macrophages

M Ulanova, S Asfaha, G Stenton, A Lint… - Journal of …, 2007 - journals.sagepub.com
Syk kinase is best known as a critical component of immunoreceptor signaling in leukocytes.
Activation of Syk following cross-linking of Fcγ and Fcε receptors on macrophages, mast …

AQX‐1125, small molecule SHIP1 activator inhibits bleomycin‐induced pulmonary fibrosis

J Cross, GR Stenton, C Harwig, C Szabo… - British Journal of …, 2017 - Wiley Online Library
Background and Purpose The phosphatase SHIP1 negatively regulates the PI3K pathway,
and its predominant expression within cells of the haematopoietic compartment makes SHIP1 …